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    alkA DNA-3-methyladenine glycosidase II [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878163, updated on 24-Aug-2024

    Summary

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    Gene symbol
    alkA
    Gene description
    DNA-3-methyladenine glycosidase II
    Locus tag
    PA1686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1835325..1836218, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene methylthioribulose-1-phosphate dehydratase Neighboring gene acireductone dioxygenase Neighboring gene enolase-phosphatase Neighboring gene polyamine aminopropyltransferase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli. Bjelland S, et al. J Biol Chem, 1994 Dec 2. PMID 7982966
    2. Amplified expression of the tag+ and alkA+ genes in Escherichia coli: identification of gene products and effects on alkylation resistance. Kaasen I, et al. J Bacteriol, 1986 Nov. PMID 3536857, Free PMC Article
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables alkylbase DNA N-glycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA alkylation repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-3-methyladenine glycosidase II
    NP_250377.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1835325..1836218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250377.1 DNA-3-methyladenine glycosidase II [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250377.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367MGY8
      Conserved Domains (1) summary
      COG0122
      Location:18 → 297
      AlkA; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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