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    cif [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882654, updated on 11-Sep-2024

    Summary

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    Official Symbol
    cif
    Primary source
    PseudoCap:PA2934
    Locus tag
    PA2934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3289715..3290674)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene morphinone reductase Neighboring gene major facilitator superfamily transporter Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis. Bahl CD, et al. Cornea, 2017 Mar. PMID 28079684, Free PMC Article
    2. Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair. Bahl CD, et al. Protein Pept Lett, 2012 Feb. PMID 21933119, Free PMC Article
    3. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. Bahl CD, et al. J Bacteriol, 2010 Apr. PMID 20118260, Free PMC Article
    4. Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation. Bomberger JM, et al. J Biol Chem, 2014 Jan 3. PMID 24247241, Free PMC Article
    5. Pseudomonas aeruginosa inhibits endocytic recycling of CFTR in polarized human airway epithelial cells. Swiatecka-Urban A, et al. Am J Physiol Cell Physiol, 2006 Mar. PMID 16236828

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first study to show that P. aeruginosa strains with ocular pathogenicity carry the cif gene and that the presence of this gene may be enriched over its prevalence in the environment.
      Title: The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
    2. Cif is the first bacterial factor identified that inhibits TAP1 function and MHC class I antigen presentation
      Title: Pseudomonas aeruginosa Cif protein enhances the ubiquitination and proteasomal degradation of the transporter associated with antigen processing (TAP) and reduces major histocompatibility complex (MHC) class I antigen presentation.
    3. VIrulence factors AprA (alkaline proteasae) and Cif (CF transmembrane conductance regulator inhibitory factor) perturb sodium and chloride transport and osmosis in the lung.
      Title: Pouring salt on a wound: Pseudomonas aeruginosa virulence factors alter Na+ and Cl- flux in the lung.
    4. Cif defines a distinct class of alpha/beta epoxide hydrolases utilizing a His/Tyr ring-opening pair.
      Title: Pseudomonas aeruginosa Cif defines a distinct class of α/β epoxide hydrolases utilizing a His/Tyr ring-opening pair.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables epoxide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CFTR inhibitory factor
    NP_251624.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3289715..3290674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251624.1 CFTR inhibitory factor [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251624.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0M3KL26
      Conserved Domains (1) summary
      COG0596
      Location:35 → 317
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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