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    nalC [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880362, updated on 11-Sep-2024

    Summary

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    Official Symbol
    nalC
    Primary source
    PseudoCap:PA3721
    Locus tag
    PA3721
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (4166518..4167159)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene MexR antirepressor ArmR Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene FMN oxidoreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC. Ghosh S, et al. Mol Microbiol, 2011 Mar. PMID 21231970, Free PMC Article
    2. MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719. Cao L, et al. Mol Microbiol, 2004 Sep. PMID 15387820
    3. Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon: involvement of repressors NalC and MexR and the antirepressor ArmR. Starr LM, et al. PLoS One, 2012. PMID 22393435, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon involves repressors NalC and MexR and the antirepressor ArmR
      Title: Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon: involvement of repressors NalC and MexR and the antirepressor ArmR.
    2. Chlorinated phenols control the expression of the MexA, MexB and OprM by interacting with NalC.
      Title: Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator
    NP_252410.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4166518..4167159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252410.1 transcriptional regulator [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252410.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A891ZRV5
      Conserved Domains (2) summary
      pfam00440
      Location:20 → 65
      TetR_N; Bacterial regulatory proteins, tetR family
      cl23808
      Location:89 → 184
      TetR_C_11; Bacterial transcriptional repressor C-terminal
    Nucleotide Protein
    Heading Accession and Version

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