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    pagL lipid A 3-O-deacylase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881344, updated on 24-Aug-2024

    Summary

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    Gene symbol
    pagL
    Gene description
    lipid A 3-O-deacylase
    Locus tag
    PA4661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5229459..5229980, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transcriptional regulator Neighboring gene deoxyribodipyrimidine photolyase Neighboring gene glutamate racemase Neighboring gene molybdopterin biosynthesis protein MoeB Neighboring gene methyl transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway. Ernst RK, et al. J Bacteriol, 2006 Jan. PMID 16352835, Free PMC Article
    2. Dissemination of lipid A deacylases (pagL) among gram-negative bacteria: identification of active-site histidine and serine residues. Geurtsen J, et al. J Biol Chem, 2005 Mar 4. PMID 15611102
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. function and regulation of the P. aeruginosa PagL homolog encoded by PA4661 and its role in the generation of cystic fibrosis-specific lipid A modifications
      Title: The Pseudomonas aeruginosa lipid A deacylase: selection for expression and loss within the cystic fibrosis airway.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid A metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipid A 3-O-deacylase
    NP_253350.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5229459..5229980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253350.1 lipid A 3-O-deacylase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253350.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HVD1
      Conserved Domains (1) summary
      pfam09411
      Location:38 → 169
      PagL; Lipid A 3-O-deacylase (PagL)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HVD1.1

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