Cdc42ep5 CDC42 effector protein 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc42ep5provided by MGI
Official Full Name: CDC42 effector protein 5provided by MGI
Primary source: MGI:MGI:1929745
See related: Ensembl:ENSMUSG00000063838 AllianceGenome:MGI:1929745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CEP5; Borg3; 1700027J19Rik; 2010007O02Rik
Summary: Predicted to enable small GTPase binding activity. Acts upstream of or within JNK cascade and Rho protein signal transduction. Located in cytoplasm and plasma membrane. Orthologous to human CDC42EP5 (CDC42 effector protein 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 230.1), colon adult (RPKM 182.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.4 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4154259..4167830, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4151260..4164831, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.
Title: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C85526 (e-PCR)
- UniSTS:179511

NoName (e-PCR)
- UniSTS:235582

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pseudopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of pseudopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cdc42 effector protein 5

Names: CDC42 effector protein (Rho GTPase binding) 5; CRIB-containing BORG3 protein; binder of Rho GTPase 3; binder of Rho GTPases 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021454.4 → NP_067429.1 cdc42 effector protein 5

See identical proteins and their annotated locations for NP_067429.1

Status: VALIDATED

Source sequence(s)

AC101941

Consensus CDS

CCDS20733.1

UniProtKB/Swiss-Prot

Q3SYK1, Q9QZT9, Q9Z0X0

Related

ENSMUSP00000092508.5, ENSMUST00000076831.7

Conserved Domains (2) summary

cl00113
Location:23 → 49

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

pfam14957
Location:85 → 110

BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4154259..4167830 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540250.4 → XP_006540313.1 cdc42 effector protein 5 isoform X2

See identical proteins and their annotated locations for XP_006540313.1

UniProtKB/Swiss-Prot

Q3SYK1, Q9QZT9, Q9Z0X0

Conserved Domains (2) summary

cl00113
Location:23 → 49

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

pfam14957
Location:85 → 110

BORG_CEP; Cdc42 effector
XM_006540249.5 → XP_006540312.1 cdc42 effector protein 5 isoform X1

Conserved Domains (2) summary

cl00113
Location:32 → 58

CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

pfam14957
Location:94 → 119

BORG_CEP; Cdc42 effector