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    Nipal2 NIPA-like domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 223473, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nipal2provided by MGI
    Official Full Name
    NIPA-like domain containing 2provided by MGI
    Primary source
    MGI:MGI:1924488
    See related
    Ensembl:ENSMUSG00000038879 AllianceGenome:MGI:1924488
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npal2; 9330161F08Rik
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be active in membrane. Is expressed in stomach. Orthologous to human NIPAL2 (NIPA like domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in stomach adult (RPKM 4.2), bladder adult (RPKM 2.5) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nipal2 in Genome Data Viewer
    Location:
    15 B3.1; 15 14.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34572942..34679739, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34572796..34679207, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_38330 Neighboring gene predicted gene, 22208 Neighboring gene RIKEN cDNA 4930413F20 gene Neighboring gene predicted gene, 53873 Neighboring gene predicted gene, 53874 Neighboring gene predicted gene, 32970 Neighboring gene predicted gene, 53875

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NIPA-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145469.5 → NP_663444.2  NIPA-like protein 2

      See identical proteins and their annotated locations for NP_663444.2

      Status: PROVISIONAL

      Source sequence(s)
      AC130713, AC152940
      Consensus CDS
      CCDS37058.1
      UniProtKB/Swiss-Prot
      Q8CC43, Q91WC7
      UniProtKB/TrEMBL
      A0A0R4J0G3
      Related
      ENSMUSP00000038922.8, ENSMUST00000040791.9
      Conserved Domains (1) summary
      cl23754
      Location:45 → 332
      EamA; EamA-like transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34572942..34679739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520055.5 → XP_006520118.1  NIPA-like protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8CC43, Q91WC7
      Conserved Domains (1) summary
      cl23754
      Location:45 → 312
      EamA; EamA-like transporter family

    2. XM_006520056.5 → XP_006520119.1  NIPA-like protein 2 isoform X2

      Conserved Domains (1) summary
      cl23754
      Location:29 → 214
      EamA; EamA-like transporter family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WC7.1 GenPept UniProtKB/Swiss-Prot:Q91WC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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