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    Ppdpf pancreatic progenitor cell differentiation and proliferation factor [ Mus musculus (house mouse) ]

    Gene ID: 66496, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppdpfprovided by MGI
    Official Full Name
    pancreatic progenitor cell differentiation and proliferation factorprovided by MGI
    Primary source
    MGI:MGI:1913746
    See related
    Ensembl:ENSMUSG00000016344 AllianceGenome:MGI:1913746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610012G23Rik; 2610317A05Rik; 2700038C09Rik; 3110053G12Rik
    Summary
    Acts upstream of or within TORC1 signaling and liver development. Is expressed in several structures, including esophagus; forelimb bud; and male reproductive gland or organ. Used to study metabolic dysfunction-associated steatotic liver disease. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 79.8), colon adult (RPKM 67.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppdpf in Genome Data Viewer
    Location:
    2 H4; 2 103.62 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180828615..180830297)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181186822..181188504)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene STARR-seq mESC enhancer starr_06747 Neighboring gene predicted gene, 24892 Neighboring gene STARR-positive B cell enhancer ABC_E6039 Neighboring gene PTK6 protein tyrosine kinase 6 Neighboring gene predicted gene, 40033 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1. Ni QZ, et al. Adv Sci (Weinh), 2023 Jan. PMID 36453576, Free PMC Article
    2. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Zheng QW, et al. Oncogene, 2022 Sep. PMID 35906391
    3. PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1. Wang YK, et al. Cell Rep, 2023 Apr 25. PMID 37027301
    4. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Ma N, et al. Nat Commun, 2021 May 24. PMID 34031390, Free PMC Article
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1.
      Title: PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1.
    2. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1.
      Title: PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1.
    3. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
      Title: PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within TOR signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pancreatic progenitor cell differentiation and proliferation factor
    Names
    exocrine differentiation and proliferation factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356427.2 → NP_001343356.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL450341
      Consensus CDS
      CCDS17202.1
      UniProtKB/Swiss-Prot
      Q58EU5, Q9CR37
      Related
      ENSMUSP00000104469.2, ENSMUST00000108841.2
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 110
      PPDFL; Differentiation and proliferation regulator

    2. NM_001356428.2 → NP_001343357.1  pancreatic progenitor cell differentiation and proliferation factor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL450341
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 84
      PPDFL; Differentiation and proliferation regulator

    3. NM_025598.4 → NP_079874.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

      See identical proteins and their annotated locations for NP_079874.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AL450341
      Consensus CDS
      CCDS17202.1
      UniProtKB/Swiss-Prot
      Q58EU5, Q9CR37
      Related
      ENSMUSP00000016488.7, ENSMUST00000016488.13
      Conserved Domains (1) summary
      pfam15060
      Location:1 → 110
      PPDFL; Differentiation and proliferation regulator

    RNA

    1. NR_151465.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL450341
      Related
      ENSMUST00000146089.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180828615..180830297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR37.1 GenPept UniProtKB/Swiss-Prot:Q9CR37

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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