Csnk2a2 casein kinase 2, alpha prime polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Csnk2a2provided by MGI
Official Full Name: casein kinase 2, alpha prime polypeptideprovided by MGI
Primary source: MGI:MGI:88547
See related: Ensembl:ENSMUSG00000046707 AllianceGenome:MGI:88547
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CK2; 1110035J23Rik
Summary: Enables protein serine/threonine kinase activity. Acts upstream of or within protein phosphorylation; regulation of cell cycle; and spermatogenesis. Predicted to be located in acrosomal vesicle and chromatin. Predicted to be part of PcG protein complex and protein kinase CK2 complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study male infertility. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 14.5), CNS E11.5 (RPKM 7.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5- D1; 8 47.12 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (96172724..96215505, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (95446096..95488868, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CK2 activity is crucial for proper glucagon expression.
Title: CK2 activity is crucial for proper glucagon expression.
CK2 negatively regulates the extinction of remote fear memory.
Title: CK2 negatively regulates the extinction of remote fear memory.
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Title: Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Title: Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Loss of lamin A in Lmna-knockout mouse embryonic fibroblasts (MEFs) confers increased CK2 activity. Conversely, prelamin A that accumulates in Zmpste24-deficent MEFs exhibits a high CK2alpha binding affinity and concomitantly reduces CK2 kinase activity
Title: Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
Results show that CK2alpha' subunit has a primary role in GN11 neuronal cell adhesion and reducing migration properties of GN11 cells by activating the Akt-GSK3beta axis, whereas CK2alpha subunit is dispensable.
Title: Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.
Phosphosites notoriously generated by CK2 are not fully abrogated in CK2 alpha/alpha'((-/-)) cells, while some phosphosites unrelated to CK2 are significantly altered. CK2 promotes phosphoproteomics perturbations attributable to kinases other than CK2.
Title: Re-evaluation of protein kinase CK2 pleiotropy: new insights provided by a phosphoproteomics analysis of CK2 knockout cells.
We found that C/EBPbeta is phosphorylated by CK2 under AMPK suppression and ER stress, which are important from the viewpoint of the worsening pathological condition of type 2 diabetes, such as decreased insulin secretion and apoptosis of pancreatic beta cells/
Title: Casein kinase 2 phosphorylates and stabilizes C/EBPβ in pancreatic β cells.
Data (including data from studies using knockout mice) suggest that Brg1 is phosphorylated by casein kinase 2 (Ck2; Ck2alpha1 and Ck2alpha-prime are catalytic subunits) in proliferating skeletal myoblasts; Brg1 is catalytic subunit of SWI/SNF chromatin-remodeling enzymes; Ck2-mediated phosphorylation of Brg1 appears to regulate myoblast proliferation. (Brg1 = Brahma-related gene 1 protein)
Title: Casein kinase 2-mediated phosphorylation of Brahma-related gene 1 controls myoblast proliferation and contributes to SWI/SNF complex composition.
data implicate CK2 as a regulator of the Th17/Treg axis and Th17 cell maturation and suggest that CK2 could be targeted for the treatment of Th17 cell-driven autoimmune disorders.
Title: Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csnk2a2 (e-PCR), detects polymorphism
- UniSTS:141421

RH126242 (e-PCR)
- UniSTS:162950

Csnk2a2 (e-PCR), detects polymorphism
- UniSTS:206983

Csnk2a2 (e-PCR), detects polymorphism
- UniSTS:206984

Csnk2a2 (e-PCR), detects polymorphism
- UniSTS:206985

Csnk2a2 (e-PCR), detects polymorphism
- UniSTS:506824

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of chromosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of chromosome separation	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromosome separation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: casein kinase II subunit alpha'

Names: CK II alpha'; casein kinase II, alpha 2, polypeptide

NP_034104.1

EC 2.7.11.1

XP_006530704.1

EC 2.7.11.1

XP_006530705.1

EC 2.7.11.1

XP_006530706.1

EC 2.7.11.1

XP_030099139.1

EC 2.7.11.1

XP_036009637.1

EC 2.7.11.1

XP_036009638.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009974.3 → NP_034104.1 casein kinase II subunit alpha'

Status: VALIDATED

Source sequence(s)

AC165414, AK002927, AK030035, BM963966, CB056745

Consensus CDS

CCDS22562.1

UniProtKB/Swiss-Prot

O54833

UniProtKB/TrEMBL

Q545V8, Q8BPF9

Related

ENSMUSP00000055919.8, ENSMUST00000056919.9

Conserved Domains (1) summary

cd14132
Location:22 → 326

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

96172724..96215505 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530641.5 → XP_006530704.1 casein kinase II subunit alpha' isoform X1

UniProtKB/TrEMBL

Q8BPF9

Conserved Domains (1) summary

cd14132
Location:22 → 275

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_006530643.4 → XP_006530706.1 casein kinase II subunit alpha' isoform X2

UniProtKB/TrEMBL

A0A1D5RM74

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_006530642.2 → XP_006530705.1 casein kinase II subunit alpha' isoform X2

UniProtKB/TrEMBL

A0A1D5RM74

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_030243279.2 → XP_030099139.1 casein kinase II subunit alpha' isoform X2

UniProtKB/TrEMBL

A0A1D5RM74

Related

ENSMUSP00000148660.2, ENSMUST00000212616.2

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_036153744.1 → XP_036009637.1 casein kinase II subunit alpha' isoform X2

UniProtKB/TrEMBL

A0A1D5RM74

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
XM_036153745.1 → XP_036009638.1 casein kinase II subunit alpha' isoform X2

UniProtKB/TrEMBL

A0A1D5RM74

Conserved Domains (1) summary

cd14132
Location:1 → 189

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2