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    Tacc1 transforming, acidic coiled-coil containing protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 320165, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tacc1provided by MGI
    Official Full Name
    transforming, acidic coiled-coil containing protein 1provided by MGI
    Primary source
    MGI:MGI:2443510
    See related
    Ensembl:ENSMUSG00000065954 AllianceGenome:MGI:2443510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833447E04Rik; B230378H13Rik
    Summary
    Enables nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein domain specific binding activity. Acts upstream of or within microtubule cytoskeleton organization; nervous system development; and regulation of microtubule-based process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and respiratory system. Orthologous to human TACC1 (transforming acidic coiled-coil containing protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 20.7), bladder adult (RPKM 18.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tacc1 in Genome Data Viewer
    Location:
    8 A2; 8 13.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25644568..25730901, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25154552..25256424, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143 Neighboring gene microRNA 8108 Neighboring gene STARR-seq mESC enhancer starr_20967 Neighboring gene STARR-seq mESC enhancer starr_20968 Neighboring gene predicted gene, 39144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26384741-26384933 Neighboring gene predicted gene, 39145

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Raha S, et al. Eur J Immunol, 2016 Sep. PMID 27338930
    2. Temporal and spatial expression of TACC1 in the mouse and human. Lauffart B, et al. Dev Dyn, 2006 Jun. PMID 16496324
    3. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Schuendeln MM, et al. Mol Cell Biol, 2004 Jul. PMID 15226440, Free PMC Article
    4. The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. Guyot R, et al. BMC Mol Biol, 2010 Jan 15. PMID 20078863, Free PMC Article
    5. Molecular contribution to cleft palate production in cleft lip mice. Sasaki Y, et al. Congenit Anom (Kyoto), 2014 May. PMID 24206222, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 4833447E04Rik, B230378H13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear estrogen receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear glucocorticoid receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear retinoic acid receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome proliferator activated receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transforming acidic coiled-coil-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402841.1 → NP_001389770.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114589

    2. NM_001402842.1 → NP_001389771.1  transforming acidic coiled-coil-containing protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114589

    3. NM_001402843.1 → NP_001389772.1  transforming acidic coiled-coil-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC114589

    4. NM_177089.6 → NP_796063.3  transforming acidic coiled-coil-containing protein 1 long isoform

      See identical proteins and their annotated locations for NP_796063.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the long isoform.
      Source sequence(s)
      AC114589
      Consensus CDS
      CCDS40303.1
      UniProtKB/Swiss-Prot
      Q05A66, Q6Y685, Q6Y686
      UniProtKB/TrEMBL
      F8VQ95
      Related
      ENSMUSP00000081043.5, ENSMUST00000084030.6
      Conserved Domains (3) summary
      pfam05010
      Location:570 → 769
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:675 → 768
      FadA; Adhesion protein FadA
      cl21478
      Location:577 → 662
      ATP-synt_B; ATP synthase B/B' CF(0)

    5. NM_199323.4 → NP_955355.1  transforming acidic coiled-coil-containing protein 1 short isoform

      See identical proteins and their annotated locations for NP_955355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This encodes the short isoform, compared to the long isoform.
      Source sequence(s)
      AC114589
      Consensus CDS
      CCDS40302.1
      UniProtKB/Swiss-Prot
      Q6Y685
      Related
      ENSMUSP00000081560.5, ENSMUST00000084512.11
      Conserved Domains (1) summary
      pfam05010
      Location:162 → 361
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25644568..25730901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y685.1 GenPept UniProtKB/Swiss-Prot:Q6Y685

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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