Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pla2g7provided by MGI
Official Full Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)provided by MGI
Primary source: MGI:MGI:1351327
See related: Ensembl:ENSMUSG00000023913 AllianceGenome:MGI:1351327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAF-AH
Summary: Predicted to enable 1-alkyl-2-acetylglycerophosphocholine esterase activity; calcium-independent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in several processes, including glycerophospholipid catabolic process; plasma lipoprotein particle remodeling; and positive regulation of monocyte chemotaxis. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular space. Predicted to be part of high-density lipoprotein particle and low-density lipoprotein particle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 43.2), frontal lobe adult (RPKM 30.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B3; 17 19.74 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (43879009..43923093)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (43567994..43612202)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
Title: Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2/STAT3 pathway.
Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis.
Title: Integrated analysis of single-cell and bulk RNA sequencing reveals pro-fibrotic PLA2G7(high) macrophages in pulmonary fibrosis.
Caloric restriction in humans reveals immunometabolic regulators of health span.
Title: Caloric restriction in humans reveals immunometabolic regulators of health span.
Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
Title: Association of circulating PLA2G7 levels with cancer cachexia and assessment of darapladib as a therapy.
Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.
Title: Platelet-Activating Factor Deteriorates Lysophosphatidylcholine-Induced Demyelination Via Its Receptor-Dependent and -Independent Effects.
PLA2G7 silencing can improve the myocardial fibrosis in mice with coronary atherosclerosis, and PLA2G7 is expected to be a potential target for coronary atherosclerosis
Title: Regulation of lipoprotein-associated phospholipase A2 silencing on myocardial fibrosis in mice with coronary atherosclerosis.
Resveratrol downregulates Lp-PLA2 expression by inhibiting oxidative stress via SIRT1 pathway in a mouse model of chronic inflammation.
Title: Resveratrol suppresses lipoprotein-associated phospholipase A(2) expression by reducing oxidative stress in macrophages and animal models.
Lp-PLA2 augments the inflammatory response after MI and antagonizes healing by disrupting the balance between inflammation and repair.
Title: Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages.
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
Title: Mouse plasminogen has oxidized phosphatidylcholine adducts that are not metabolized by lipoprotein-associated phospholipase A₂under basal conditions.
SAA up-regulates Lp-PLA2 production significantly via a FPRL1/MAPKs./PPAR-gamma signaling pathway.
Title: Serum amyloid A stimulates lipoprotein-associated phospholipase A2 expression in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125227 (e-PCR)
- UniSTS:162049

Pla2g2f (e-PCR), detects polymorphism
- UniSTS:507147

Pla2g7 (e-PCR), detects polymorphism
- UniSTS:526092

D17Mit168 (e-PCR), detects polymorphism
- UniSTS:127991

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO Inferred from Sequence Orthology more info
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-independent phospholipase A2 activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipid oxidation	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma lipoprotein particle oxidation	IEA Inferred from Electronic Annotation more info
involved_in plasma lipoprotein particle oxidation	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet activating factor metabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: platelet-activating factor acetylhydrolase

Names: 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase

NP_001412035.1

EC 3.1.1.47

NP_038765.2

EC 3.1.1.47

XP_006524429.1

EC 3.1.1.47

XP_006524430.1

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425106.1 → NP_001412035.1 platelet-activating factor acetylhydrolase precursor

Status: VALIDATED

Source sequence(s)

CT010585

UniProtKB/Swiss-Prot

Q60963, Q8BKM3, Q921T4
NM_013737.6 → NP_038765.2 platelet-activating factor acetylhydrolase precursor

See identical proteins and their annotated locations for NP_038765.2

Status: VALIDATED

Source sequence(s)

CT010585

Consensus CDS

CCDS28796.1

UniProtKB/Swiss-Prot

Q60963, Q8BKM3, Q921T4

Related

ENSMUSP00000024706.6, ENSMUST00000024706.12

Conserved Domains (1) summary

pfam03403
Location:47 → 415

PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

43879009..43923093

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524366.4 → XP_006524429.1 platelet-activating factor acetylhydrolase isoform X1

See identical proteins and their annotated locations for XP_006524429.1

UniProtKB/Swiss-Prot

Q60963, Q8BKM3, Q921T4

Conserved Domains (1) summary

pfam03403
Location:47 → 415

PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II
XM_006524367.4 → XP_006524430.1 platelet-activating factor acetylhydrolase isoform X2

Conserved Domains (1) summary

pfam03403
Location:24 → 392

PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II