Zc3h14 zinc finger CCCH type containing 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3h14provided by MGI
Official Full Name: zinc finger CCCH type containing 14provided by MGI
Primary source: MGI:MGI:1919824
See related: Ensembl:ENSMUSG00000021012 AllianceGenome:MGI:1919824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1010001P15Rik; 1700016A15Rik; 2700069A02Rik
Summary: Predicted to enable poly(A) binding activity. Predicted to be involved in regulation of mRNA stability. Located in nuclear speck. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 56. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 36.2), CNS E11.5 (RPKM 18.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 E; 12 49.88 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (98708276..98754033)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (98742017..98787774)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of nuclear ZC3H14-interacting proteins from the brain and links the functions of ZC3H14 and the THO complex in the processing of RNA.
Title: The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts.
Among the proteins increased in the hippocampi of Zc3h14Deltaex13/Deltaex13 mice compared to control are key synaptic proteins including CaMK2a. This newly generated mouse serves as a tool to study the function of ZC3H14 in vivo.
Title: The RNA-binding protein, ZC3H14, is required for proper poly(A) tail length control, expression of synaptic proteins, and brain function in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

12.MMHAP91FLD3.seq (e-PCR)
- UniSTS:123137

18.MMHAP70FLF3.seq (e-PCR)
- UniSTS:123396

AU014748 (e-PCR)
- UniSTS:180444

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axon cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger CCCH domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008506.2 → NP_001008506.2 zinc finger CCCH domain-containing protein 14 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.

Source sequence(s)

AC159193, AK048046, AK076066, AK160937

Consensus CDS

CCDS26099.1

UniProtKB/Swiss-Prot

Q8BJ05

Related

ENSMUSP00000105731.3, ENSMUST00000110104.10

Conserved Domains (1) summary

pfam14608
Location:490 → 508

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001160107.1 → NP_001153579.1 zinc finger CCCH domain-containing protein 14 isoform c

See identical proteins and their annotated locations for NP_001153579.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three alternate exons in the central coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.

Source sequence(s)

AC159193, AK048046, AK076066, AK160937

Consensus CDS

CCDS49138.1

UniProtKB/Swiss-Prot

Q8BJ05

Related

ENSMUSP00000055879.10, ENSMUST00000057000.17

Conserved Domains (1) summary

pfam14608
Location:525 → 541

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001160108.1 → NP_001153580.1 zinc finger CCCH domain-containing protein 14 isoform d

See identical proteins and their annotated locations for NP_001153580.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform a.

Source sequence(s)

AC159193, AK006009, AK160937, BU936221

Consensus CDS

CCDS49139.1

UniProtKB/Swiss-Prot

Q8BJ05

Related

ENSMUSP00000021399.8, ENSMUST00000021399.9

Conserved Domains (1) summary

COG5084
Location:179 → 273

YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
NM_001364400.1 → NP_001351329.1 zinc finger CCCH domain-containing protein 14 isoform e

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:677 → 693

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001364401.1 → NP_001351330.1 zinc finger CCCH domain-containing protein 14 isoform f

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:656 → 672

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001364402.1 → NP_001351331.1 zinc finger CCCH domain-containing protein 14 isoform g

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:546 → 562

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001364403.1 → NP_001351332.1 zinc finger CCCH domain-containing protein 14 isoform h

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:526 → 542

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001364404.1 → NP_001351333.1 zinc finger CCCH domain-containing protein 14 isoform i

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:395 → 411

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_001364405.1 → NP_001351334.1 zinc finger CCCH domain-containing protein 14 isoform j

Status: VALIDATED

Source sequence(s)

AC159193

Conserved Domains (1) summary

pfam14608
Location:370 → 386

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
NM_029334.2 → NP_083610.2 zinc finger CCCH domain-containing protein 14 isoform a

See identical proteins and their annotated locations for NP_083610.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC159193, AK048046, AK076066, AK160937

Consensus CDS

CCDS26100.1

UniProtKB/Swiss-Prot

A0PJE7, A1A4A9, Q3TU70, Q8BIY8, Q8BJ05, Q8R3Q8, Q8R3R2, Q9DAA8

Related

ENSMUSP00000105732.3, ENSMUST00000110105.10

Conserved Domains (1) summary

pfam14608
Location:621 → 639

zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RNA

NR_027648.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region and three alternate exons in the central coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC159193, AK076066, AK160937

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

98708276..98754033

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516327.4 → XP_006516390.3 zinc finger CCCH domain-containing protein 14 isoform X1

Conserved Domains (1) summary

pfam14608
Location:739 → 755

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
XM_006516328.4 → XP_006516391.3 zinc finger CCCH domain-containing protein 14 isoform X2

Conserved Domains (1) summary

pfam14608
Location:714 → 730

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
XM_006516330.4 → XP_006516393.3 zinc finger CCCH domain-containing protein 14 isoform X4

Conserved Domains (1) summary

pfam14608
Location:583 → 599

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
XM_006516329.4 → XP_006516392.3 zinc finger CCCH domain-containing protein 14 isoform X3

Conserved Domains (1) summary

pfam14608
Location:608 → 624

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
XM_030246973.2 → XP_030102833.1 zinc finger CCCH domain-containing protein 14 isoform X5

Conserved Domains (1) summary

pfam14608
Location:501 → 517

zf-CCCH_2; RNA-binding, Nab2-type zinc finger
XM_006516333.3 → XP_006516396.1 zinc finger CCCH domain-containing protein 14 isoform X6

Conserved Domains (1) summary

pfam14608
Location:386 → 402

zf-CCCH_2; RNA-binding, Nab2-type zinc finger