Zdhhc6 zinc finger, DHHC domain containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zdhhc6provided by MGI
Official Full Name: zinc finger, DHHC domain containing 6provided by MGI
Primary source: MGI:MGI:1914230
See related: Ensembl:ENSMUSG00000024982 AllianceGenome:MGI:1914230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DHHC-6; 2400007G07Rik; 5930409M18Rik
Summary: Predicted to enable protein-cysteine S-palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in protein palmitoylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including eye; genitourinary system; heart; lung epithelium; and trunk somite. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 8.6), kidney adult (RPKM 8.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.33 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (55286648..55304468, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (55298216..55316036, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.
Title: Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126152 (e-PCR)
- UniSTS:162864

D10S1390E (e-PCR)
- UniSTS:151387

AI462345 (e-PCR)
- UniSTS:160860

D19Mit55 (e-PCR), detects polymorphism
- UniSTS:128397

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-stearoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine S-stearoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of mitochondrial fusion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein palmitoylation	ISO Inferred from Sequence Orthology more info
involved_in protein stearoylation	ISO Inferred from Sequence Orthology more info
involved_in protein stearoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC6

Names: H4 homolog; stearoyltransferase ZDHHC6; zinc finger DHHC domain-containing protein 6

NP_001028745.1

EC 2.3.1.225

NP_001347524.1

EC 2.3.1.225

NP_080159.3

EC 2.3.1.225

XP_006527331.1

EC 2.3.1.225

XP_011245618.1

EC 2.3.1.225

XP_030106892.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033573.2 → NP_001028745.1 palmitoyltransferase ZDHHC6 isoform 1

See identical proteins and their annotated locations for NP_001028745.1

Status: VALIDATED

Source sequence(s)

AC133100, AK050388, AK159304, BY109555

Consensus CDS

CCDS29909.1

UniProtKB/Swiss-Prot

Q3U3I8, Q3UT70, Q544H1, Q9CPV7

Related

ENSMUSP00000076157.6, ENSMUST00000076891.7

Conserved Domains (2) summary

pfam01529
Location:95 → 241

DHHC; DHHC palmitoyltransferase

pfam07653
Location:317 → 396

SH3_2; Variant SH3 domain
NM_001360595.1 → NP_001347524.1 palmitoyltransferase ZDHHC6 isoform 2

Status: VALIDATED

Source sequence(s)

AC133100

Conserved Domains (1) summary

pfam01529
Location:95 → 241

zf-DHHC; DHHC palmitoyltransferase
NM_025883.4 → NP_080159.3 palmitoyltransferase ZDHHC6 isoform 1

See identical proteins and their annotated locations for NP_080159.3

Status: VALIDATED

Source sequence(s)

AC133100, AK159304

Consensus CDS

CCDS29909.1

UniProtKB/Swiss-Prot

Q3U3I8, Q3UT70, Q544H1, Q9CPV7

Related

ENSMUSP00000153014.2, ENSMUST00000224897.2

Conserved Domains (2) summary

pfam01529
Location:95 → 241

DHHC; DHHC palmitoyltransferase

pfam07653
Location:317 → 396

SH3_2; Variant SH3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

55286648..55304468 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247316.3 → XP_011245618.1 palmitoyltransferase ZDHHC6 isoform X1

See identical proteins and their annotated locations for XP_011245618.1

UniProtKB/Swiss-Prot

Q3U3I8, Q3UT70, Q544H1, Q9CPV7

Conserved Domains (2) summary

pfam01529
Location:95 → 241

DHHC; DHHC palmitoyltransferase

pfam07653
Location:317 → 396

SH3_2; Variant SH3 domain
XM_006527268.4 → XP_006527331.1 palmitoyltransferase ZDHHC6 isoform X1

See identical proteins and their annotated locations for XP_006527331.1

UniProtKB/Swiss-Prot

Q3U3I8, Q3UT70, Q544H1, Q9CPV7

Conserved Domains (2) summary

pfam01529
Location:95 → 241

DHHC; DHHC palmitoyltransferase

pfam07653
Location:317 → 396

SH3_2; Variant SH3 domain
XM_030251032.1 → XP_030106892.1 palmitoyltransferase ZDHHC6 isoform X2

Conserved Domains (1) summary

pfam07653
Location:213 → 292

SH3_2; Variant SH3 domain