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    Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 14924, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Magi1provided by MGI
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1provided by MGI
    Primary source
    MGI:MGI:1203522
    See related
    Ensembl:ENSMUSG00000045095 AllianceGenome:MGI:1203522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AIP3; BAP1; WWP3; Baiap1; Gukmi1; MAGI1c; Magi-1; TNRC19; mKIAA4129
    Summary
    Predicted to enable alpha-actinin binding activity. Involved in endothelial cell morphogenesis. Located in several cellular components, including adherens junction; cytoplasm; and nucleus. Is expressed in several structures, including facial prominence; genitourinary system; liver; musculoskeletal system; and spleen. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 9.8), whole brain E14.5 (RPKM 9.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Magi1 in Genome Data Viewer
    Location:
    6 D1; 6 42.7 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (93652434..94260906, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (93675453..94283929, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22312 Neighboring gene STARR-seq mESC enhancer starr_16685 Neighboring gene STARR-seq mESC enhancer starr_16686 Neighboring gene STARR-seq mESC enhancer starr_16687 Neighboring gene STARR-seq mESC enhancer starr_16688 Neighboring gene ribosomal protein P0 pseudogene Neighboring gene predicted gene, 53322 Neighboring gene VISTA enhancer mm1316 Neighboring gene STARR-seq mESC enhancer starr_16692 Neighboring gene predicted gene, 23035 Neighboring gene predicted gene, 22840 Neighboring gene STARR-seq mESC enhancer starr_16697 Neighboring gene STARR-seq mESC enhancer starr_16699 Neighboring gene RIKEN cDNA 4930511A08 gene Neighboring gene STARR-seq mESC enhancer starr_16702 Neighboring gene STARR-seq mESC enhancer starr_16704 Neighboring gene predicted gene, 31661 Neighboring gene predicted gene, 19908

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins. Glaunsinger BA, et al. Oncogene, 2000 Nov 2. PMID 11077444, Free PMC Article
    2. MAGI1 inhibits interferon signaling to promote influenza A infection. Wang Y, et al. Front Cardiovasc Med, 2022. PMID 36082118, Free PMC Article
    3. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis. Matsuzawa K, et al. Commun Biol, 2021 Mar 12. PMID 33712709, Free PMC Article
    4. Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Wegmann F, et al. Exp Cell Res, 2004 Oct 15. PMID 15383320
    5. Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis. Murata M, et al. Cell Tissue Res, 2005 Feb. PMID 15558322

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
      Title: MAGIs regulate aPKC to enable balanced distribution of intercellular tension for epithelial sheet homeostasis.
    2. Study in mouse model of atherosclerosis suggests that MAGI1 simultaneously regulates endothelial cells activation and endoplasmic reticulum stress-induced apoptosis, which are critical molecular events for atherogenesis, via MAGI1-S741 phosphorylation by p90RSK and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation.
      Title: MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.
    3. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure
      Title: MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.
    4. Cx32 expression is in part related to induction of tight junctions through modulation of Magi1 expression in an immortalized hepatic cell line.
      Title: Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.
    5. ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct.
      Title: Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells.
    6. Data conclude that the up-regulation of sdk-1 in podocytes is an important pathogenic factor in glomerulosclerosis and that the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI-1 function.
      Title: Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis.
    7. Depletion of MAGI-1 from photorecptors by RNA interference blocks synaptic localization of Sidekick-2 in photoreceptors without affecting localization of postsynaptic density (PSD)-95.
      Title: Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins.
    8. MAGI-1 together with JAM4 provides an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells
      Title: JAM4, a junctional cell adhesion molecule interacting with a tight junction protein, MAGI-1.
    9. We found MAGI-1 to be associated with cell-cell contacts in human umbilical vein endothelial cells (HUVECs) and in mouse endothelium, where it colocalizes with ESAM.
      Title: Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts.
    10. Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system
      Title: MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4129

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-actinin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endothelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Names
    BAI1-associated protein 1
    membrane-associated guanylate kinase inverted 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029850.5 → NP_001025021.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (c).
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS20377.1
      UniProtKB/Swiss-Prot
      O54893, O54894, O54895, Q6RHR9
      UniProtKB/TrEMBL
      B9EKC0
      Related
      ENSMUSP00000086730.6, ENSMUST00000089317.12
      Conserved Domains (6) summary
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1132 → 1214
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:988 → 1071
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    2. NM_001083320.3 → NP_001076789.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure and has multiple differences in the coding region, compared to variant 3. It encodes isoform b, which is shorter than isoform c.
      Source sequence(s)
      AC138381, AC153601
      Consensus CDS
      CCDS39573.1
      UniProtKB/TrEMBL
      E9PZ12, Q5DTM1
      Related
      ENSMUSP00000091283.6, ENSMUST00000093769.8
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916 → 998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:974 → 1223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:760 → 855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:489 → 570
      MAGI_u5; Unstructured region on MAGI

    3. NM_001083321.3 → NP_001076790.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform d, which is shorter and has a distinct C-terminus, compared to isoform c. Variants 1, 27, and 29 all encode the same isoform (d).
      Source sequence(s)
      AC138381, AC153601
      Consensus CDS
      CCDS85098.1
      UniProtKB/TrEMBL
      A0A0N4SWH0, Q5DTM1
      Related
      ENSMUSP00000145515.2, ENSMUST00000203688.3
      Conserved Domains (6) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916 → 998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:76 → 105
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:761 → 855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    4. NM_001286784.2 → NP_001273713.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes isoform e, which is shorter than isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0, Q4H4B4
      Conserved Domains (6) summary
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1131 → 1213
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:976 → 1070
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349 → 378
      WW; WW domain
      pfam16666
      Location:702 → 785
      MAGI_u5; Unstructured region on MAGI

    5. NM_001286785.2 → NP_001273714.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site and includes an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 3. It encodes isoform f, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS85099.1
      UniProtKB/TrEMBL
      A0A0N4SUZ0, B9EKC0
      Related
      ENSMUSP00000144881.2, ENSMUST00000204347.3
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1144 → 1226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:988 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    6. NM_001286786.2 → NP_001273715.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains multiple coding region differences compared to variant 3, and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform g, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      UniProtKB/TrEMBL
      B9EKC0, Q4H4B5
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1131 → 1213
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:976 → 1070
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:702 → 785
      MAGI_u5; Unstructured region on MAGI

    7. NM_001286788.2 → NP_001273717.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has multiple differences, compared to variant 3. These differences cause translation initiation at a downstream start codon and result in a different 3' coding region and 3' UTR, compared to variant 3. It encodes isoform h, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (6) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:914 → 996
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:76 → 105
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:759 → 853
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    8. NM_001409967.1 → NP_001396896.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382

    9. NM_001409968.1 → NP_001396897.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382

    10. NM_001409969.1 → NP_001396898.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    11. NM_001409970.1 → NP_001396899.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    12. NM_001409971.1 → NP_001396900.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    13. NM_001409972.1 → NP_001396901.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    14. NM_001409973.1 → NP_001396902.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601, AC162382
      Related
      ENSMUSP00000145244.2, ENSMUST00000203519.3

    15. NM_001409974.1 → NP_001396903.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    16. NM_001409975.1 → NP_001396904.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    17. NM_001409976.1 → NP_001396905.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    18. NM_001409978.1 → NP_001396907.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    19. NM_001409979.1 → NP_001396908.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    20. NM_001409980.1 → NP_001396909.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    21. NM_001409982.1 → NP_001396911.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    22. NM_001409983.1 → NP_001396912.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    23. NM_001409984.1 → NP_001396913.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    24. NM_001409985.1 → NP_001396914.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    25. NM_001409986.1 → NP_001396915.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      A0A0N4SWH0

    26. NM_001409987.1 → NP_001396916.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    27. NM_001409988.1 → NP_001396917.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601
      UniProtKB/TrEMBL
      A0A0N4SWH0

    28. NM_001409989.1 → NP_001396918.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    29. NM_001409990.1 → NP_001396919.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform y

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    30. NM_001409991.1 → NP_001396920.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform z

      Status: VALIDATED

      Source sequence(s)
      AC138381, AC153601

    31. NM_010367.4 → NP_034497.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains multiple coding region differences, one of which results in a frameshift and an early stop codon, compared to variant 3. It encodes isoform a, which is shorter and has a distinct C-terminus, compared to isoform c.
      Source sequence(s)
      AC138381, AC153601, AC162382
      Consensus CDS
      CCDS20378.1
      UniProtKB/TrEMBL
      A0A0R4J0S6, Q4VBG2
      Related
      ENSMUSP00000062085.9, ENSMUST00000055224.15
      Conserved Domains (6) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1035 → 1117
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:798 → 873
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:702 → 784
      MAGI_u5; Unstructured region on MAGI

    RNA

    1. NR_104594.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has multiple differences compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC138381, AC153601
      Related
      ENSMUST00000204532.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      93652434..94260906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505586.3 → XP_006505649.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:349 → 380
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1132 → 1214
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1190 → 1439
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:976 → 1071
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:702 → 785
      MAGI_u5; Unstructured region on MAGI

    2. XM_036165869.1 → XP_036021762.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1075 → 1157
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1133 → 1382
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:838 → 913
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:716 → 797
      MAGI_u5; Unstructured region on MAGI

    3. XM_006505584.3 → XP_006505647.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1143 → 1225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1201 → 1450
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:987 → 1082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:714 → 796
      MAGI_u5; Unstructured region on MAGI

    4. XM_030255179.2 → XP_030111039.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1048 → 1130
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1106 → 1355
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:811 → 886
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    5. XM_006505600.3 → XP_006505663.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X36

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1115 → 1197
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1173 → 1422
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:960 → 1054
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    6. XM_036165867.1 → XP_036021760.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1116 → 1198
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1174 → 1423
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:960 → 1055
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:716 → 804
      MAGI_u5; Unstructured region on MAGI

    7. XM_030255186.2 → XP_030111046.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X32

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1076 → 1158
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:839 → 914
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    8. XM_006505601.4 → XP_006505664.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X37

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1143 → 1225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:988 → 1082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    9. XM_006505581.3 → XP_006505644.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:361 → 392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1144 → 1226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1202 → 1451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:988 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:714 → 797
      MAGI_u5; Unstructured region on MAGI

    10. XM_036165868.1 → XP_036021761.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1076 → 1158
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1134 → 1383
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:839 → 914
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:717 → 798
      MAGI_u5; Unstructured region on MAGI

    11. XM_030255184.2 → XP_030111044.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1143 → 1225
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:988 → 1082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 797
      MAGI_u5; Unstructured region on MAGI

    12. XM_006505583.3 → XP_006505646.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1144 → 1226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1202 → 1451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:988 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 797
      MAGI_u5; Unstructured region on MAGI

    13. XM_036165876.1 → XP_036021769.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X31

      UniProtKB/TrEMBL
      Q4VBG2
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1105 → 1187
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:961 → 1044
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:717 → 805
      MAGI_u5; Unstructured region on MAGI

    14. XM_006505588.3 → XP_006505651.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1116 → 1198
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1174 → 1423
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:961 → 1055
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    15. XM_006505587.3 → XP_006505650.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1117 → 1199
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1175 → 1424
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:961 → 1056
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    16. XM_036165872.1 → XP_036021765.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1117 → 1199
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:961 → 1056
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:717 → 805
      MAGI_u5; Unstructured region on MAGI

    17. XM_006505589.3 → XP_006505652.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1077 → 1159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1135 → 1384
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:840 → 915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    18. XM_017321400.3 → XP_017176889.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1077 → 1159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:840 → 915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    19. XM_036165873.1 → XP_036021766.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1077 → 1159
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:840 → 915
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:717 → 799
      MAGI_u5; Unstructured region on MAGI

    20. XM_006505585.3 → XP_006505648.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1133 → 1215
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1191 → 1440
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:989 → 1072
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    21. XM_017321399.3 → XP_017176888.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1133 → 1215
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:989 → 1072
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    22. XM_006505582.3 → XP_006505645.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1144 → 1226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1202 → 1451
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:989 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    23. XM_006505593.4 → XP_006505656.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1144 → 1226
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:989 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    24. XM_006505580.3 → XP_006505643.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (7) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1145 → 1227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:1203 → 1452
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:989 → 1084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:302 → 331
      WW; WW domain
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    25. XM_006505592.3 → XP_006505655.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1145 → 1227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:989 → 1084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    26. XM_006505591.3 → XP_006505654.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

      UniProtKB/TrEMBL
      B9EKC0
      Conserved Domains (6) summary
      smart00456
      Location:362 → 393
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122 → 293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:1145 → 1227
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303 → 332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:989 → 1084
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:715 → 798
      MAGI_u5; Unstructured region on MAGI

    27. XM_036165874.1 → XP_036021767.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:122 → 153
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:905 → 987
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:963 → 1212
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:749 → 844
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:477 → 559
      MAGI_u5; Unstructured region on MAGI

    28. XM_006505599.5 → XP_006505662.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917 → 999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:975 → 1224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761 → 856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    29. XM_006505594.5 → XP_006505657.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:918 → 1000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:976 → 1225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762 → 857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488 → 571
      MAGI_u5; Unstructured region on MAGI

    30. XM_030255181.2 → XP_030111041.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917 → 999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:975 → 1224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761 → 856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    31. XM_006505596.4 → XP_006505659.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:918 → 1000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:976 → 1225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762 → 857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488 → 571
      MAGI_u5; Unstructured region on MAGI

    32. XM_006505597.5 → XP_006505660.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:135 → 166
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:918 → 1000
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:976 → 1225
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:762 → 857
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:488 → 571
      MAGI_u5; Unstructured region on MAGI

    33. XM_030255183.2 → XP_030111043.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916 → 998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:974 → 1223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761 → 855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    34. XM_006505598.5 → XP_006505661.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

      UniProtKB/TrEMBL
      Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:917 → 999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:975 → 1224
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:761 → 856
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:487 → 570
      MAGI_u5; Unstructured region on MAGI

    35. XM_036165871.1 → XP_036021764.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

      UniProtKB/TrEMBL
      E9PZ12, Q5DTM1
      Conserved Domains (7) summary
      smart00456
      Location:134 → 165
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:916 → 998
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      PRK12678
      Location:974 → 1223
      PRK12678; transcription termination factor Rho; Provisional
      cd00992
      Location:760 → 855
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:75 → 104
      WW; WW domain
      pfam16663
      Location:1 → 34
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:489 → 570
      MAGI_u5; Unstructured region on MAGI
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RHR9.1 GenPept UniProtKB/Swiss-Prot:Q6RHR9

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