Racgap1 Rac GTPase-activating protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Racgap1provided by MGI
Official Full Name: Rac GTPase-activating protein 1provided by MGI
Primary source: MGI:MGI:1349423
See related: Ensembl:ENSMUSG00000023015 AllianceGenome:MGI:1349423
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gtl11; Band25; GTPase; MgcRacGAP; mKIAA1478
Summary: Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Involved in neuroblast proliferation and regulation of embryonic development. Predicted to be located in cytoplasmic side of plasma membrane; mitotic spindle; and nucleoplasm. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and nose. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 49.5), liver E14 (RPKM 31.3) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.13 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (99518377..99549504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (99620496..99651656, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Title: RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
Title: Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.
APC(CDH1) targets MgcRacGAP for destruction in the late M phase.
Title: APC(CDH1) targets MgcRacGAP for destruction in the late M phase.
TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases.
Title: TLR4 signaling shapes B cell dynamics via MyD88-dependent pathways and Rac GTPases.
several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac, CDC42, and RhoG small GTPase activities
Title: Cooperative activation of PI3K by Ras and Rho family small GTPases.
This study demonstrated that loss of Rac1 attenuates synapse structure and function in vivo, which ultimately leads to significant defects in spatial learning and working/episodic-like memory.
Title: A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory.
mgcRacGAP is now shown to play a indispensable role in the development of hematopoietic cells in vivo.
Title: Essential roles of mgcRacGAP in multilineage differentiation and survival of murine hematopoietic cells.
Rac became activated within 2 min after peripheral membrane extensions adhered to new ECM islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island
Title: Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation.
alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase-Cdc42/Rac pathways may play a role in determining the size and shape of tooth germ
Title: Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.
These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.
Title: Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136016 (e-PCR)
- UniSTS:210012

NoName (e-PCR)
- UniSTS:237405

AI327394 (e-PCR)
- UniSTS:180833

RH126612 (e-PCR)
- UniSTS:209144

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	ISO Inferred from Sequence Orthology more info
involved_in actomyosin contractile ring assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle midzone assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in sulfate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
part_of centralspindlin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of centralspindlin complex	ISO Inferred from Sequence Orthology more info
part_of centralspindlin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rac GTPase-activating protein 1

Names: male germ cell RacGap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253808.2 → NP_001240737.1 rac GTPase-activating protein 1

See identical proteins and their annotated locations for NP_001240737.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.

Source sequence(s)

AC139317

Consensus CDS

CCDS27825.1

UniProtKB/Swiss-Prot

Q3THR5, Q3TI41, Q3TM81, Q9WVM1

Related

ENSMUSP00000023756.6, ENSMUST00000023756.12

Conserved Domains (3) summary

cd04382
Location:347 → 540

RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...

pfam00261
Location:43 → 108

Tropomyosin

cd20821
Location:286 → 339

C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
NM_001253809.2 → NP_001240738.1 rac GTPase-activating protein 1

See identical proteins and their annotated locations for NP_001240738.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks a segment in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.

Source sequence(s)

AC139317

Consensus CDS

CCDS27825.1

UniProtKB/Swiss-Prot

Q3THR5, Q3TI41, Q3TM81, Q9WVM1

Conserved Domains (3) summary

cd04382
Location:347 → 540

RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...

pfam00261
Location:43 → 108

Tropomyosin

cd20821
Location:286 → 339

C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins
NM_001411865.1 → NP_001398794.1 rac GTPase-activating protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.

Source sequence(s)

AC139317

UniProtKB/Swiss-Prot

Q3THR5, Q3TI41, Q3TM81, Q9WVM1
NM_001411866.1 → NP_001398795.1 rac GTPase-activating protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-5 encode the same protein.

Source sequence(s)

AC139317

UniProtKB/Swiss-Prot

Q3THR5, Q3TI41, Q3TM81, Q9WVM1
NM_012025.8 → NP_036155.1 rac GTPase-activating protein 1

See identical proteins and their annotated locations for NP_036155.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longest transcript. Variants 1-5 encode the same protein.

Source sequence(s)

AC139317

Consensus CDS

CCDS27825.1

UniProtKB/Swiss-Prot

Q3THR5, Q3TI41, Q3TM81, Q9WVM1

Related

ENSMUSP00000126417.2, ENSMUST00000171702.8

Conserved Domains (3) summary

cd04382
Location:347 → 540

RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...

pfam00261
Location:43 → 108

Tropomyosin

cd20821
Location:286 → 339

C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins