Npr1 natriuretic peptide receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npr1provided by MGI
Official Full Name: natriuretic peptide receptor 1provided by MGI
Primary source: MGI:MGI:97371
See related: Ensembl:ENSMUSG00000027931 AllianceGenome:MGI:97371
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GC-A; NPRA; Pndr; NPR-A
Summary: Enables guanylate cyclase activity. Involved in regulation of blood pressure. Predicted to be located in membrane. Predicted to be part of ANPR-A receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; respiratory system; and ventricle cardiac muscle. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 198.6), ovary adult (RPKM 80.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.23 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90357898..90373235, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90450591..90465928, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.
Title: Epigenetic mechanisms differentially regulate blood pressure and renal dysfunction in male and female Npr1 haplotype mice.
Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.
Title: Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi.
The landscape of N6-methyladenosine modification patterns and altered transcript profiles in the cardiac-specific deletion of natriuretic peptide receptor A.
Title: The landscape of N6-methyladenosine modification patterns and altered transcript profiles in the cardiac-specific deletion of natriuretic peptide receptor A.
Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
Title: Lack of NPR1 Increases Vascular Endothelial Adhesion through Induction of Integrin Beta 4.
Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-beta1/SMAD Signaling Pathway.
Title: Genetic Disruption of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Triggers Differential Cardiac Fibrosis and Disorders in Male and Female Mutant Mice: Role of TGF-β1/SMAD Signaling Pathway.
Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
Title: Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Title: BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk.
Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice.
Title: Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice.
GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.
Title: GRPR/Extracellular Signal-Regulated Kinase and NPRA/Extracellular Signal-Regulated Kinase Signaling Pathways Play a Critical Role in Spinal Transmission of Chronic Itch.
Cardiacspecific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice.
Title: Cardiac‑specific deletion of natriuretic peptide receptor A induces differential myocardial expression of circular RNA and mRNA molecules involved in metabolism in mice.

Submit: New GeneRIF Correction See all GeneRIFs (82)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Npr1 (e-PCR), detects polymorphism
- UniSTS:526954

Npr1 (e-PCR), detects polymorphism
- UniSTS:525461

AI893888 (e-PCR)
- UniSTS:178887

PMC199554P1 (e-PCR)
- UniSTS:271868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables natriuretic peptide receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cGMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ANPR-A receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: atrial natriuretic peptide receptor 1

Names: ANP-A; ANPR-A; Nppa receptor; atrial natriuretic peptide receptor type A; guanylate cyclase A; guanylyl cyclase-A

NP_032753.5

EC 4.6.1.2

XP_006501177.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008727.5 → NP_032753.5 atrial natriuretic peptide receptor 1 precursor

See identical proteins and their annotated locations for NP_032753.5

Status: VALIDATED

Source sequence(s)

AK135008, CJ065787, L31932

Consensus CDS

CCDS17529.1

UniProtKB/Swiss-Prot

P18293

UniProtKB/TrEMBL

Q2TAY4, Q91X04

Related

ENSMUSP00000029540.7, ENSMUST00000029540.13

Conserved Domains (7) summary

cd06385
Location:32 → 439

PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor

smart00219
Location:543 → 797

TyrKc; Tyrosine kinase, catalytic domain

smart00044
Location:836 → 1025

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd14042
Location:530 → 803

PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B

pfam00211
Location:863 → 1049

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:50 → 410

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:812 → 857

HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90357898..90373235 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501114.1 → XP_006501177.1 atrial natriuretic peptide receptor 1 isoform X1

Conserved Domains (1) summary

cd06385
Location:32 → 439

PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor