Hdac10 histone deacetylase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdac10provided by MGI
Official Full Name: histone deacetylase 10provided by MGI
Primary source: MGI:MGI:2158340
See related: Ensembl:ENSMUSG00000062906 AllianceGenome:MGI:2158340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hd10
Summary: Predicted to enable histone deacetylase activity; histone deacetylase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of mismatch repair; regulation of gene expression; and spermidine deacetylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of histone deacetylase complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 30.7), thymus adult (RPKM 25.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.64 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89007506..89012903, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89123303..89128700, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
Title: Myeloid-specific Hdac10 deletion protects against LPS-induced acute lung injury via P62 acetylation at lysine 165.
Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
Title: Degradation of HDAC10 by autophagy promotes IRF3-mediated antiviral innate immune responses.
HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
Title: HDAC10 Regulates Cancer Stem-Like Cell Properties in KRAS-Driven Lung Adenocarcinoma.
HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.
Title: HDAC10 deletion promotes Foxp3(+) T-regulatory cell function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylputrescine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables acetylspermidine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
NOT enables protein lysine deacetylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in polyamine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in polyamine deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mismatch repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mismatch repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in spermidine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in spermidine deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyamine deacetylase HDAC10

NP_001403078.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403079.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403080.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403081.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403082.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403083.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403084.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403085.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403086.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403087.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403088.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403089.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403090.1

EC 3.5.1.48

EC 3.5.1.62

NP_001403091.1

EC 3.5.1.48

EC 3.5.1.62

NP_954668.2

EC 3.5.1.48

EC 3.5.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416149.1 → NP_001403078.1 polyamine deacetylase HDAC10 isoform 2

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416150.1 → NP_001403079.1 polyamine deacetylase HDAC10 isoform 3

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416151.1 → NP_001403080.1 polyamine deacetylase HDAC10 isoform 4

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416152.1 → NP_001403081.1 polyamine deacetylase HDAC10 isoform 5

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416153.1 → NP_001403082.1 polyamine deacetylase HDAC10 isoform 6

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416154.1 → NP_001403083.1 polyamine deacetylase HDAC10 isoform 7

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416155.1 → NP_001403084.1 polyamine deacetylase HDAC10 isoform 8

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416156.1 → NP_001403085.1 polyamine deacetylase HDAC10 isoform 9

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416157.1 → NP_001403086.1 polyamine deacetylase HDAC10 isoform 10

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416158.1 → NP_001403087.1 polyamine deacetylase HDAC10 isoform 11

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416159.1 → NP_001403088.1 polyamine deacetylase HDAC10 isoform 12

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416160.1 → NP_001403089.1 polyamine deacetylase HDAC10 isoform 13

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416161.1 → NP_001403090.1 polyamine deacetylase HDAC10 isoform 14

Status: VALIDATED

Source sequence(s)

AC113069
NM_001416162.1 → NP_001403091.1 polyamine deacetylase HDAC10 isoform 15

Status: VALIDATED

Source sequence(s)

AC113069
NM_199198.3 → NP_954668.2 polyamine deacetylase HDAC10 isoform 1

See identical proteins and their annotated locations for NP_954668.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein.

Source sequence(s)

AC113069

Consensus CDS

CCDS27739.1

UniProtKB/Swiss-Prot

G3X9I8, Q6P3E7

Related

ENSMUSP00000080832.6, ENSMUST00000082197.12

Conserved Domains (1) summary

cl17011
Location:18 → 354

Arginase_HDAC; Arginase-like and histone-like hydrolases

RNA

NR_028447.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC113069, AI448228, AK040235, BU706947

Related

ENSMUST00000129398.8
NR_028448.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC113069, AI448228, AK040235

Related

ENSMUST00000128908.8
NR_028449.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site and contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC113069, AI448228, AK040235, BU706947

Related

ENSMUST00000143465.8
NR_183467.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC113069