Gm4924 predicted gene 4924 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gm4924provided by MGI
Official Full Name: predicted gene 4924provided by MGI
Primary source: MGI:MGI:3643133
See related: Ensembl:ENSMUSG00000073427 AllianceGenome:MGI:3643133
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mif1; EG237412
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (82190087..82215477)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (82354525..82379643)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection.
Title: Macrophage Migration Inhibitory Factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection.
""Near Cure"" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
Title: "Near Cure" treatment of severe acute EAE in MIF-1-deficient female and male mice with a bifunctional MHCII-derived molecular construct.
Novel murine Kruppel-related factor MIF1 expressed in trigeminal ganglion contains a Kruppel-associated box (KRAB) domain but lacks a zinc-finger motif.
Title: A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: predicted gene 4924

Names: inhibitor of four 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001407604.1 → NP_001394533.1 predicted gene 4924 isoform 1

Status: VALIDATED

Source sequence(s)

AC158606, AC160865

UniProtKB/TrEMBL

A0A1B0GR71

Related

ENSMUSP00000147402.2, ENSMUST00000210381.2
NM_001407606.1 → NP_001394535.1 predicted gene 4924 isoform 2

Status: VALIDATED

Source sequence(s)

AC158606, AC160865
NM_001407607.1 → NP_001394536.1 predicted gene 4924 isoform 3

Status: VALIDATED

Source sequence(s)

AC158606, AC160865
NM_001407609.1 → NP_001394538.1 predicted gene 4924 isoform 3

Status: VALIDATED

Source sequence(s)

AC158606, AC160865

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

82190087..82215477

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314181.1 → XP_017169670.1 predicted gene 4924 isoform X1

Conserved Domains (3) summary

COG5048
Location:599 → 1008

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:689 → 709

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:43 → 84

KRAB; KRAB box
XM_036156142.1 → XP_036012035.1 predicted gene 4924 isoform X4

Conserved Domains (3) summary

COG5048
Location:349 → 756

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:381 → 401

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:43 → 84

KRAB; KRAB box