panE 2-dehydropantoate 2-reductase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: panE
Official Full Name: 2-dehydropantoate 2-reductase
Primary source: ECOCYC:G6239
Locus tag: b0425
See related: ASAP:ABE-0001474
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: apbA; ECK0419
Summary: Sequence verified by mass spectrometry (obs=33870), Met is not clipped. [More information is available at EcoGene: EG13271]. 2-Dehydropantoate 2-reductase catalyzes the NADPH-dependent reduction of ketopantoate to pantoate. [More information is available at EcoCyc: G6239].
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NC_000913.3 Genomic Context describing neighboring genes

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analysis of the roles of active site residues of ketopantoate reductase and its conformational changes in substrate recognition and catalysis
Title: Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity.
crystal structure of Escherichia coli ketopantoate reductase in complex with 2'-monophosphoadenosine 5'-diphosphoribose; binding changes with pH and mutations
Title: pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.
crystal structure of Escherichia coli KPR with NADP(+) bound, solved to 2.1 A resolution
Title: The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-dehydropantoate 2-reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-dehydropantoate 2-reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-dehydropantoate 2-reductase activity	IEA Inferred from Electronic Annotation more info
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pantothenate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_414959.1

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The following sections contain reference sequences that belong to a specific genome build. Explain