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    hycE formate hydrogenlyase subunit HycE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947396, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hycE
    Official Full Name
    formate hydrogenlyase subunit HycE
    Primary source
    ECOCYC:EG10478
    Locus tag
    b2721
    See related
    ASAP:ABE-0008944
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2716; hevE
    Summary
    FhlA regulon. [More information is available at EcoGene: EG10478]. HycE is the large subunit of hydrogenase 3 . [More information is available at EcoCyc: EG10478].
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    Genomic context

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    Sequence:
    NC_000913.3 (2844762..2846471, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 maturation protease Neighboring gene formate hydrogenlyase assembly protein Neighboring gene formate hydrogenlyase subunit HycG Neighboring gene formate hydrogenlyase subunit HycF Neighboring gene formate hydrogenlyase subunit HycD Neighboring gene formate hydrogenlyase subunit HycC Neighboring gene formate hydrogenlyase subunit HycB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nickel incorporation into hydrogenase 3 from Escherichia coli requires the precursor form of the large subunit. Binder U, et al. Arch Microbiol, 1996 Jan. PMID 8639025
    2. Redox sensing by Escherichia coli: effects of copper ions as oxidizers on proton-coupled membrane transport. Kirakosyan G, et al. Bioelectrochemistry, 2007 Jan. PMID 16713752
    3. Protein engineering of hydrogenase 3 to enhance hydrogen production. Maeda T, et al. Appl Microbiol Biotechnol, 2008 May. PMID 18335216
    4. Differential expression of hydrogenase isoenzymes in Escherichia coli K-12: evidence for a third isoenzyme. Sawers RG, et al. J Bacteriol, 1985 Dec. PMID 3905769, Free PMC Article
    5. Analysis of the cleavage site specificity of the endopeptidase involved in the maturation of the large subunit of hydrogenase 3 from Escherichia coli. Theodoratou E, et al. Arch Microbiol, 2000 Feb. PMID 10795682

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hydrogen-dependent reduction of benzyl viologen in hydrogenases HyaB, HybC and HybE is dependent on the [Fe-S]-cluster-containing small subunit.
      Title: Efficient electron transfer from hydrogen to benzyl viologen by the [NiFe]-hydrogenases of Escherichia coli is dependent on the coexpression of the iron-sulfur cluster-containing small subunit.
    2. N-terminus verified by Edman degradation on complete protein
      Title: Maturation of the large subunit (HYCE) of Escherichia coli hydrogenase 3 requires nickel incorporation followed by C-terminal processing at Arg537.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formate oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of formate dehydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formate hydrogenlyase subunit HycE
    NP_417201.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2844762..2846471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417201.1 formate hydrogenlyase subunit HycE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417201.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M3I4, A0A6D0IAP2
      Conserved Domains (2) summary
      COG3261
      Location:172 → 552
      HycE2; Ni,Fe-hydrogenase III large subunit [Energy production and conversion]
      COG3262
      Location:2 → 166
      HycE1; Ni,Fe-hydrogenase III component G [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version

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