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    malY negative regulator of MalT activity/cystathionine beta-lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945937, updated on 3-Dec-2024

    Summary

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    Official Symbol
    malY
    Official Full Name
    negative regulator of MalT activity/cystathionine beta-lyase
    Primary source
    ECOCYC:EG10564
    Locus tag
    b1622
    See related
    ASAP:ABE-0005432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1617
    Summary
    MalY is a bifunctional protein with a regulatory as well as an enzymatic function. [More information is available at EcoCyc: EG10564].
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    Genomic context

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    Sequence:
    NC_000913.3 (1700957..1702129)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene PTS enzyme IIBC component MalX Neighboring gene adenosine deaminase Neighboring gene putative oxidoreductase YdgJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli. Bertoldi M, et al. Biochem J, 2005 Aug 1. PMID 15823094, Free PMC Article
    2. Structural basis for negative regulation of the Escherichia coli maltose system. Wu Y, et al. Nat Commun, 2023 Aug 15. PMID 37582800, Free PMC Article
    3. A proteomic approach to study Escherichia coli. Acetyl esterase interactors unveil a sequence motif involved in protein-protein interaction. D'Ambrosio C, et al. Protein Pept Lett, 2008. PMID 18473943
    4. Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Commichau FM, et al. Mol Microbiol, 2008 Feb. PMID 18086213
    5. Effect of cysteine desulfhydrase gene disruption on L-cysteine overproduction in Escherichia coli. Awano N, et al. Appl Microbiol Biotechnol, 2003 Aug. PMID 12883870

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables L-cysteine desulfhydrase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-S-conjugate beta-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    negative regulator of MalT activity/cystathionine beta-lyase
    NP_416139.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1700957..1702129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416139.1 negative regulator of MalT activity/cystathionine beta-lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416139.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EDP5
      Conserved Domains (1) summary
      COG1168
      Location:1 → 390
      MalY; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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