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    Arp5 Actin-related protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42173, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arp5provided by FlyBase
    Official Full Name
    Actin-related protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038576
    Locus tag
    Dmel_CG7940
    See related
    AllianceGenome:FB:FBgn0038576
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7940; dArp5; Dmel\CG7940
    Summary
    Involved in regulation of DNA-templated transcription. Located in nucleus. Part of Ino80 complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and ventral nerve cord primordium. Orthologous to human ACTR5 (actin related protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arp5 in Genome Data Viewer
    Location:
    90F6-90F6; 3-62 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18185498..18187875)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14011220..14013597)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 5 Neighboring gene well-rounded Neighboring gene cadmus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 17 Neighboring gene uncharacterized protein Neighboring gene Sequence-specific single-stranded DNA-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Actin-related protein 6 facilitates proneural protein-induced gene activation for rapid neural differentiation. Hsiao YL, et al. Development, 2023 Mar 1. PMID 36897355
    2. A Burst of Genetic Innovation in Drosophila Actin-Related Proteins for Testis-Specific Function. Schroeder CM, et al. Mol Biol Evol, 2020 Mar 1. PMID 31697328, Free PMC Article
    3. A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Klymenko T, et al. Genes Dev, 2006 May 1. PMID 16618800, Free PMC Article
    4. The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development. Niederhuber MJ, et al. Genetics, 2024 Feb 7. PMID 37949841, Free PMC Article
    5. The biology of chromatin remodeling complexes. Clapier CR, et al. Annu Rev Biochem, 2009. PMID 19355820

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-related protein 5
    Names
    Arp5-PA
    Arp5-PB
    CG7940-PA
    CG7940-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18185498..18187875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142427.4 → NP_650684.1  Actin-related protein 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VEC3
      UniProtKB/TrEMBL
      A0A0B4KG83
      Related
      FBpp0082979
      Conserved Domains (1) summary
      COG5277
      Location:1 → 637
      COG5277; Actin-related protein [Cytoskeleton]

    2. NM_001275768.1 → NP_001262697.1  Actin-related protein 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262697.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VEC3
      UniProtKB/TrEMBL
      A0A0B4KG83
      Conserved Domains (1) summary
      COG5277
      Location:1 → 637
      COG5277; Actin-related protein [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG83 A0A0B4KG83
    Q9VEC3.1 Q9VEC3

    Gene LinkOut

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