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    kud kuduk [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kudprovided by FlyBase
    Official Full Name
    kudukprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036667
    Locus tag
    Dmel_CG9669
    See related
    AllianceGenome:FB:FBgn0036667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9669; Dmel\CG9669; Kud
    Summary
    Involved in nuclear envelope organization and nuclear migration. Located in endoplasmic reticulum membrane and nuclear outer membrane. Orthologous to human TMEM258 (transmembrane protein 258). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kud in Genome Data Viewer
    Location:
    73D1-73D1; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16844568..16844991, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16837668..16838091, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nudC Neighboring gene uncharacterized protein Neighboring gene Tumor susceptibility gene 101 Neighboring gene uncharacterized protein Neighboring gene Zinc finger CCHC-type containing 7 Neighboring gene Rhodopsin 4 Neighboring gene seven in absentia

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. Ding ZY, et al. J Cell Biol, 2017 Sep 4. PMID 28716842, Free PMC Article
    2. Many P-element insertions affect wing shape in Drosophila melanogaster. Weber K, et al. Genetics, 2005 Mar. PMID 15545659, Free PMC Article
    3. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. den Hoed M, et al. Nat Genet, 2013 Jun. PMID 23583979, Free PMC Article
    4. Comparative transcriptional analysis uncovers molecular processes in early and mature somatic cyst cells of Drosophila testes. Adashev VE, et al. Eur J Cell Biol, 2022 Jun-Aug. PMID 35667338
    5. A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification. Li Y, et al. Nat Commun, 2024 Mar 6. PMID 38448482, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear envelope organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kuduk
    Names
    CG9669-PA
    CG9669-PB
    kud-PA
    kud-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16844568..16844991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259878.1 → NP_001246807.1  kuduk, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246807.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVA8
      UniProtKB/TrEMBL
      G2J5U1, Q6NP26
      Conserved Domains (1) summary
      pfam05251
      Location:5 → 78
      Ost5; Oligosaccharyltransferase subunit 5

    2. NM_140668.3 → NP_648925.1  kuduk, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVA8
      UniProtKB/TrEMBL
      G2J5U1, Q6NP26
      Related
      FBpp0075098
      Conserved Domains (1) summary
      pfam05251
      Location:5 → 78
      Ost5; Oligosaccharyltransferase subunit 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G2J5U1 G2J5U1
    Q9VVA8.1 Q9VVA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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