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    PIG-X Phosphatidylinositol glycan anchor biosynthesis class X [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246580, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Xprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Xprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050381
    Locus tag
    Dmel_CG30381
    See related
    AllianceGenome:FB:FBgn0050381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30381; Dmel\CG30381
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human PIGX (phosphatidylinositol glycan anchor biosynthesis class X). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-X in Genome Data Viewer
    Location:
    43F2-43F2; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7929658..7931016, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3817163..3818521, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cullin 1 Neighboring gene Odorant receptor 43b Neighboring gene Lysine demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene ribonuclease H1 Neighboring gene drosha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
    2. Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep. Palermo J, et al. Sci Adv, 2023 Jan 6. PMID 36608130, Free PMC Article
    3. NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. Singh MD, et al. PLoS Genet, 2020 Feb. PMID 32053595, Free PMC Article
    4. GPI biosynthesis is essential for rhodopsin sorting at the trans-Golgi network in Drosophila photoreceptors. Satoh T, et al. Development, 2013 Jan 15. PMID 23250212
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class X
    Names
    CG30381-PB
    CG30381-PC
    PIG-X-PB
    PIG-X-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7929658..7931016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103751.2 → NP_001097221.1  phosphatidylinositol glycan anchor biosynthesis class X, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY62, F3YDB9
      Conserved Domains (1) summary
      pfam08320
      Location:3 → 212
      PIG-X; PIG-X / PBN1

    2. NM_001299243.1 → NP_001286172.1  phosphatidylinositol glycan anchor biosynthesis class X, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LES9, F3YDB9
      Conserved Domains (1) summary
      pfam08320
      Location:3 → 218
      PIG-X; PIG-X / PBN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LES9 A0A0B4LES9
    A8DY62 A8DY62

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