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    Mco3 Multicopper oxidase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mco3provided by FlyBase
    Official Full Name
    Multicopper oxidase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039387
    Locus tag
    Dmel_CG5959
    See related
    AllianceGenome:FB:FBgn0039387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5959; dMCO3; Dmel\CG5959; MCO3; MIP26036
    Summary
    Enables ferroxidase activity. Involved in copper ion homeostasis. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mco3 in Genome Data Viewer
    Location:
    96F7-96F7; 3-89 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25897476..25899744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21723198..21725466)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sodesque Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43259 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila multicopper oxidase 3 is a potential ferroxidase involved in iron homeostasis. Wang X, et al. Biochim Biophys Acta Gen Subj, 2018 Aug. PMID 29684424
    2. Insect multicopper oxidases: diversity, properties, and physiological roles. Dittmer NT, et al. Insect Biochem Mol Biol, 2010 Mar. PMID 20219675
    3. Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase. Bettedi L, et al. J Exp Biol, 2011 Mar 15. PMID 21346125
    4. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
    5. Molecular physiology of iron trafficking in Drosophila melanogaster. Wu S, et al. Curr Opin Insect Sci, 2022 Apr. PMID 35158107

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCO3 mutants had a mild accumulation of copper, which was suppressed in Mvl mutants, revealing a reciprocal genetic interaction between the two genes.
      Title: Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferroxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multicopper oxidase 3
    Names
    CG5959-PA
    Mco3-PA
    multicopper oxidase
    NP_651441.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25897476..25899744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143184.2 → NP_651441.1  multicopper oxidase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651441.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E0R946, Q9VBK7
      Related
      FBpp0084314
      Conserved Domains (4) summary
      cd13858
      Location:149 → 252
      CuRO_1_tcLCC2_insect_like; The first cupredoxin domain of insect laccases similar to laccase 2 in Tribolium castaneum
      cd13884
      Location:270 → 408
      CuRO_2_tcLCC_insect_like; The second cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      cd13905
      Location:502 → 671
      CuRO_3_tcLLC2_insect_like; The third cupredoxin domain of the insect laccases similar to laccase 2 in Tribolium castaneum
      TIGR03389
      Location:151 → 656
      laccase; laccase, plant
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBK7 Q9VBK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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