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    Gld2 GLD2 poly(A) polymerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gld2provided by FlyBase
    Official Full Name
    GLD2 poly(A) polymeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038934
    Locus tag
    Dmel_CG5732
    See related
    AllianceGenome:FB:FBgn0038934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5732; Dm1; DmCG5732; Dmel\CG5732; DmGLD2; GLD-2; GLD2; TUTase2
    Summary
    Enables poly(A) RNA polymerase activity. Involved in long-term memory. Located in cytoplasm; neuron projection; and nucleoplasm. Is expressed in organism; spermatocyte; spermatocyte cyst; and testis. Orthologous to human TENT2 (terminal nucleotidyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gld2 in Genome Data Viewer
    Location:
    94A3-94A3; 3-74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22211824..22217415)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18037546..18043137)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Shal K[+] channel interacting protein Neighboring gene long non-coding RNA:CR45224 Neighboring gene mir-1010 stem loop Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The poly(A) polymerase GLD2 is required for spermatogenesis in Drosophila melanogaster. Sartain CV, et al. Development, 2011 Apr. PMID 21427144, Free PMC Article
    2. GLD2 poly(A) polymerase is required for long-term memory. Kwak JE, et al. Proc Natl Acad Sci U S A, 2008 Sep 23. PMID 18780789, Free PMC Article
    3. A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans. Wang L, et al. Nature, 2002 Sep 19. PMID 12239571
    4. Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Modepalli V, et al. Genome Biol Evol, 2017 Jun 1. PMID 28633361, Free PMC Article
    5. PAP- and GLD-2-type poly(A) polymerases are required sequentially in cytoplasmic polyadenylation and oogenesis in Drosophila. Benoit P, et al. Development, 2008 Jun. PMID 18434412, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GLD2 poly(A) polymerase
    Names
    3' terminal uridylyl transferase 2
    CG5732-PB
    CG5732-PC
    Gld2-PB
    Gld2-PC
    NP_001262829.1
    NP_651012.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22211824..22217415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275900.1 → NP_001262829.1  GLD2 poly(A) polymerase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJK9, Q8MR77, Q9VD44
      UniProtKB/TrEMBL
      A0A0B4KGP2
      Conserved Domains (2) summary
      cd05402
      Location:954 → 1073
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1163 → 1224
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_142755.4 → NP_651012.2  GLD2 poly(A) polymerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651012.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJK9, Q8MR77, Q9VD44
      UniProtKB/TrEMBL
      A0A0B4KGP2
      Related
      FBpp0293575
      Conserved Domains (2) summary
      cd05402
      Location:954 → 1073
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:1163 → 1224
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGP2 A0A0B4KGP2
    Q9VD44.3 Q9VD44

    Gene LinkOut

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