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    Sk2 Sphingosine kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sk2provided by FlyBase
    Official Full Name
    Sphingosine kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0052484
    Locus tag
    Dmel_CG32484
    See related
    AllianceGenome:FB:FBgn0052484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2159; CG32484; Dmel\CG32484; sk2; SK2; Sphk2; SphK2
    Summary
    Enables D-erythro-sphingosine kinase activity. Involved in egg-laying behavior; flight behavior; and sphingolipid metabolic process. Located in lysosomal membrane. Is expressed in adult head; anterior midgut primordium; mesoderm; organism; and posterior midgut primordium. Used to study cardiomyopathy and obesity. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Sk2 in Genome Data Viewer
    Location:
    63A3-63A4; 3-5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3047087..3050159)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3047087..3050159)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 4 Neighboring gene scramblase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glial Sphingosine-Mediated Epigenetic Regulation Stabilizes Synaptic Function in Drosophila Models of Alzheimer's Disease. Yin P, et al. J Neurosci, 2023 Oct 18. PMID 37669862, Free PMC Article
    2. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. Herr DR, et al. J Biol Chem, 2004 Mar 26. PMID 14722126
    3. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. Fyrst H, et al. J Lipid Res, 2008 Mar. PMID 18156591
    4. Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption. Villanueva JE, et al. Nat Commun, 2019 Jun 20. PMID 31221967, Free PMC Article
    5. Sphingosine kinases and their metabolites modulate endolysosomal trafficking in photoreceptors. Yonamine I, et al. J Cell Biol, 2011 Feb 21. PMID 21321100, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sk1 and Sk2 are not redundant in biological function and are essential for diverse physiological functions in Drosophila
      Title: Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-erythro-sphingosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-erythro-sphingosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine kinase 2
    Names
    CG32484-PA
    Sk2-PA
    sphingosine kinase
    sphingosine kinase II
    NP_647762.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3047087..3050159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139505.4 → NP_647762.3  sphingosine kinase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647762.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0C1, Q9VZW0
      Related
      FBpp0072854
      Conserved Domains (2) summary
      PLN02958
      Location:213 → 639
      PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
      pfam00781
      Location:216 → 354
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZW0 Q9VZW0

    Gene LinkOut

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