CG3999 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG3999provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037801
Locus tag: Dmel_CG3999
See related: AllianceGenome:FB:FBgn0037801
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Dmel\CG3999
Summary: Predicted to enable glycine binding activity; glycine dehydrogenase (decarboxylating) activity; and pyridoxal phosphate binding activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; embryonic/larval fat body; fat body/gonad primordium; and yolk nucleus. Used to study glycine encephalopathy. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GLDC (glycine decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10251518..10255268)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6077240..6080990)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycine binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycine dehydrogenase (decarboxylating) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine dehydrogenase (decarboxylating) activity	IEA Inferred from Electronic Annotation more info
enables glycine dehydrogenase (decarboxylating) activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in glycine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine decarboxylation via glycine cleavage system	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine decarboxylation via glycine cleavage system	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of glycine cleavage complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glycine cleavage complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

NP_001262456.1

NP_649989.1

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The following sections contain reference sequences that belong to a specific genome build. Explain