Galphaq G protein alpha subunit q [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Galphaqprovided by FlyBase
Official Full Name: G protein alpha subunit qprovided by FlyBase
Primary source: FLYBASE:FBgn0004435
Locus tag: Dmel_CG17759
See related: AllianceGenome:FB:FBgn0004435
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17759; dGaalpha; DGalphaq; DGalpha[[q]]; dgq; dGq; Dgq; DGq; dGqa-49b; dgqalpha; dGqalpha; DGqalpha; dGqalpha-3; dGqalpha-49b; dG[[alphaq]]; dG[[q]]alpha; Dmel\CG17759; DmGalpha[[q]]; Dromel_CG17759_galpha49b_mORF; G alpha 49B; G?q; Galpha; galpha49B; Galpha49b; Galpha49B; Galpha[[q]]; Gaq; GNAQ/11/14; Gq; Gqa-3; Gqalpha; Gqalphae; Gqalpha[[e]]; Gqalpha{e}; G[q]; G[[alphaq]]; G[[a]]q; G[[qalpha]]; G[[q]]; G[[q]]alpha; sast
Summary: Enables G protein activity and phospholipase activator activity. Involved in several processes, including cellular response to carbon dioxide; negative regulation of compound eye retinal cell programmed cell death; and negative regulation of phospholipase C-activating phototransduction signaling pathway. Located in rhabdomere. Part of inaD signaling complex. Is expressed in several structures, including embryonic/larval midgut primordium; organism subdivision; photoreceptor; sensory neurons; and synaptic neuropil domain. Used to study obesity. Human ortholog(s) of this gene implicated in Sturge-Weber syndrome; autosomal dominant hypocalcemia 2; congestive heart failure; familial hypocalciuric hypercalcemia 2; and familial multiple nevi flammei. Orthologous to several human genes including GNA11 (G protein subunit alpha 11) and GNAQ (G protein subunit alpha q). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 49B8-49B9; 2-67 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12612740..12623197)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8500245..8510702)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galphaq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila.
Title: Gαq splice variants mediate phototransduction, rhodopsin synthesis, and retinal integrity in Drosophila.
A single residue mutation in the G-Protein, Gq, causes blindness in Drosophila.
Title: A Single Residue Mutation in the Gα(q) Subunit of the G Protein Complex Causes Blindness in Drosophila.
microRNA-9a regulates dendrite growth through cadherin protein Flamingo-G protein Galphaq signaling in Drosophila sensory neurons
Title: Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons.
Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila.
Title: Gαq, Gγ1 and Plc21C control Drosophila body fat storage.
Gq modulates termination of phototransduction and prevents retinal degeneration
Title: Protein Gq modulates termination of phototransduction and prevents retinal degeneration.
the Galphaq-PLCbeta-Ca(2+)-DUOX-ROS signaling pathway acts as a bona fide first line of defense that enables gut epithelia to dynamically control yeast during the Drosophila life cycle
Title: Regulation of DUOX by the Galphaq-phospholipase Cbeta-Ca2+ pathway in Drosophila gut immunity.
Reduced odor responses from antennal neurons of G(q)alpha mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
Data suggest that prolonged G(q) activity triggers rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity in Drosophila.
Title: Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity.
Data suggest that the photoreceptor-specific myosin III NINAC is involved in G(q)alpha transport in Drosophila photoreceptors.
Title: Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC.
demonstrated that light causes massive and reversible translocation of the visual Gqalpha to the cytosol, associated with marked architectural changes in the photoreceptors
Title: Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phospholipase activator activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of compound eye retinal cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phospholipase C-activating phototransduction signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating opsin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stabilization of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of inaD signaling complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: G protein alpha subunit q

Names: CG17759-PA; CG17759-PC; CG17759-PD; CG17759-PE; CG17759-PG; CG17759-PJ; CG17759-PK; G protein 49B; G protein alpha q subunit; G protein alpha49B; G-protein alpha subunit; G-protein alpha49B; G-protein-alpha[[q]]; Galphaq-PA; Galphaq-PC; Galphaq-PD; Galphaq-PE; Galphaq-PG; Galphaq-PJ; Galphaq-PK; small amplify and slow termination

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12612740..12623197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165925.3 → NP_725197.2 G protein alpha subunit q, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725197.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P23625

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165921.2 → NP_725193.1 G protein alpha subunit q, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725193.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23625

Related

FBpp0086944

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165919.2 → NP_725191.1 G protein alpha subunit q, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725191.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23625

Related

FBpp0086942

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165923.2 → NP_725195.1 G protein alpha subunit q, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725195.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23625

Related

FBpp0086943

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165920.3 → NP_725192.2 G protein alpha subunit q, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725192.2

Status: REVIEWED

Conserved Domains (1) summary

cd00066
Location:34 → 390

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165924.2 → NP_725196.1 G protein alpha subunit q, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725196.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZE6, P23625, P54400, Q29QX1, Q540Y7, Q9I7C8, Q9V6E2

Related

FBpp0086945

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
NM_165922.2 → NP_725194.1 G protein alpha subunit q, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725194.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23625

Related

FBpp0086946

Conserved Domains (1) summary

cd00066
Location:34 → 347

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)