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    FucTC alpha1,3-fucosyltransferase C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FucTCprovided by FlyBase
    Official Full Name
    alpha1,3-fucosyltransferase Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0044872
    Locus tag
    Dmel_CG40305
    See related
    AllianceGenome:FB:FBgn0044872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40305; Dmel\CG40305
    Summary
    Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in membrane. Orthologous to human FUT5 (fucosyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FucTC in Genome Data Viewer
    Location:
    20F3-20F3; 1-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23008766..23011303, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22410602..22413139, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stoned A Neighboring gene stoned B Neighboring gene antisense RNA:CR45009 Neighboring gene long non-coding RNA:CR45010 Neighboring gene Rab21 Neighboring gene Cytochrome c oxidase assembly factor 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope. Fabini G, et al. J Biol Chem, 2001 Jul 27. PMID 11382750
    2. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. Rendic D, et al. J Biol Chem, 2006 Feb 10. PMID 16314421
    3. Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Rendić D, et al. Glycobiology, 2010 Nov. PMID 20688784, Free PMC Article
    4. Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. McNeil CL, et al. G3 (Bethesda), 2011 Oct. PMID 22384345, Free PMC Article
    5. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha1,3-fucosyltransferase C
    Names
    CG40305-PB
    FucTC-PB
    alpha1,3-fucosyltransferase
    NP_001036320.3
    • frameshift

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      23008766..23011303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042855.4 → NP_001036320.3  alpha1,3-fucosyltransferase C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036320.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83088, Q7PLF1
      Conserved Domains (2) summary
      pfam00852
      Location:241 → 410
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:82 → 203
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83088.4 P83088

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials