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    Polr3D RNA polymerase III subunit D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr3Dprovided by FlyBase
    Official Full Name
    RNA polymerase III subunit Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036775
    Locus tag
    Dmel_CG5147
    See related
    AllianceGenome:FB:FBgn0036775
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5147; dC53; Dmel\CG5147; Rpc53; RPC53; RpIIIC53
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in tRNA transcription by RNA polymerase III. Predicted to be part of RNA polymerase III complex. Is expressed in organism and spermatozoon. Orthologous to human POLR3D (RNA polymerase III subunit D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr3D in Genome Data Viewer
    Location:
    75B9-75B9; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18107848..18109574, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18100948..18102674, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene mutagen-sensitive 304 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Ureña E, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38241436, Free PMC Article
    2. RNA polymerase III limits longevity downstream of TORC1. Filer D, et al. Nature, 2017 Dec 14. PMID 29186112, Free PMC Article
    3. Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. Wood AM, et al. Mol Cell, 2011 Oct 7. PMID 21981916, Free PMC Article
    4. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    5. Drosophila histone locus bodies form by hierarchical recruitment of components. White AE, et al. J Cell Biol, 2011 May 16. PMID 21576393, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase III subunit D
    Names
    CG5147-PA
    Polr3D-PA
    RNA polymerase III subunit C53

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18107848..18109574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140771.3 → NP_649028.3  RNA polymerase III subunit D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649028.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYM9, Q95S56, Q9VVN3
      Related
      FBpp0074902
      Conserved Domains (1) summary
      pfam05132
      Location:272 → 395
      RNA_pol_Rpc4; RNA polymerase III RPC4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYM9 Q8SYM9
    Q95S56 Q95S56

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