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    CG4074 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4074provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037017
    Locus tag
    Dmel_CG4074
    See related
    AllianceGenome:FB:FBgn0037017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmDSCR3; Dmel\CG4074; DSCR3
    Summary
    Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to be part of retromer, cargo-selective complex. Predicted to be active in endosome. Orthologous to human VPS26C (VPS26 endosomal protein sorting factor C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4074 in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20768207..20769500, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20761307..20762582, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei. Koumandou VL, et al. J Cell Sci, 2011 May 1. PMID 21502137, Free PMC Article
    2. Identification of Cellular Genes Involved in Baculovirus GP64 Trafficking to the Plasma Membrane. Hodgson JJ, et al. J Virol, 2022 Jun 22. PMID 35608346, Free PMC Article
    3. Analyzing the function of a hox gene: an evolutionary approach. Michaut L, et al. Dev Growth Differ, 2011 Dec. PMID 22150153
    4. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article
    5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of retromer, cargo-selective complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4074-PC
    CG4074-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20768207..20769500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300202.2 → NP_001287131.2  uncharacterized protein Dmel_CG4074, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3Q0, Q9VPC3
      Conserved Domains (1) summary
      cl22903
      Location:6 → 289
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_140992.4 → NP_649249.2  uncharacterized protein Dmel_CG4074, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3Q0, Q9VPC3
      Conserved Domains (1) summary
      cl22903
      Location:6 → 289
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPC3 Q9VPC3

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