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    Lnk Lnk [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lnkprovided by FlyBase
    Official Full Name
    Lnkprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028717
    Locus tag
    Dmel_CG17367
    See related
    AllianceGenome:FB:FBgn0028717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 17367; CG17367; CG5908; Dmel\CG17367; dSH2B; lnk; LNK; SH2B
    Summary
    Enables transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of protein localization to cell cortex. Located in cell cortex. Is expressed in adult fat body; adult gut; adult head; hypodermal muscle cell of A1-7; and indirect flight muscle cell. Used to study chromosome 16p11.2 deletion syndrome, 220-kb. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to several human genes including SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lnk in Genome Data Viewer
    Location:
    96F6-96F6; 3-89 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25888542..25893270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21714264..21718992)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tetraspanin 96F Neighboring gene Signal peptide peptidase-like Neighboring gene uncharacterized protein Neighboring gene Sodesque

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Nairz K, et al. Genome Biol, 2004. PMID 15461801, Free PMC Article
    2. SH2B1 is Involved in the Accumulation of Amyloid-β42 in Alzheimer's Disease. Shen Y, et al. J Alzheimers Dis, 2017. PMID 27802221
    3. The Lnk/SH2B adaptor provides a fail-safe mechanism to establish the Insulin receptor-Chico interaction. Almudi I, et al. Cell Commun Signal, 2013 Apr 16. PMID 23590848, Free PMC Article
    4. Nutrient-Response Pathways in Healthspan and Lifespan Regulation. Dabrowska A, et al. Cells, 2022 May 6. PMID 35563873, Free PMC Article
    5. The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway. Werz C, et al. PLoS Genet, 2009 Aug. PMID 19680438, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phenotypic analysis of mutants for Lnk revealed that loss of Lnk function results in increased lifespan and improved survival under conditions of oxidative stress and starvation.
      Title: Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
    2. Lnk acts in parallel to Chico downstream of the insulin receptor to regulate cellular growth.
      Title: The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to cell cortex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lnk
    Names
    CG17367-PA
    CG17367-PB
    CG17367-PC
    CG17367-PD
    CG17367-PE
    CG17367-PF
    Lnk-PA
    Lnk-PB
    Lnk-PC
    Lnk-PD
    Lnk-PE
    Lnk-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25888542..25893270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170247.2 → NP_733126.1  Lnk, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K137
      Related
      FBpp0084309
      Conserved Domains (4) summary
      cd10346
      Location:433 → 529
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:197 → 308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:215 → 307
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper

    2. NM_001300608.1 → NP_001287537.1  Lnk, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHS0
      Conserved Domains (4) summary
      cd10346
      Location:438 → 534
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:202 → 313
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:220 → 312
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper

    3. NM_001300607.1 → NP_001287536.1  Lnk, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHY5
      Conserved Domains (4) summary
      cd10346
      Location:438 → 534
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:202 → 313
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:220 → 312
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper

    4. NM_170246.2 → NP_733125.1  Lnk, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K137
      Related
      FBpp0084311
      Conserved Domains (4) summary
      cd10346
      Location:433 → 529
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:197 → 308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:215 → 307
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper

    5. NM_001300609.1 → NP_001287538.1  Lnk, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIP5
      Conserved Domains (4) summary
      cd10346
      Location:433 → 529
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:197 → 308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:215 → 307
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper

    6. NM_143181.3 → NP_651438.1  Lnk, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K137
      Related
      FBpp0084310
      Conserved Domains (4) summary
      cd10346
      Location:433 → 529
      SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family
      cd01231
      Location:197 → 308
      PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
      pfam00169
      Location:215 → 307
      PH; PH domain
      pfam08916
      Location:67 → 125
      Phe_ZIP; Phenylalanine zipper
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHS0 A0A0B4LHS0
    A0A0B4LHY5 A0A0B4LHY5
    A0A0B4LIP5 A0A0B4LIP5
    Q7K137 Q7K137
    Q9U8B9 Q9U8B9

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