U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    anne anne boleyn [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317815, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    anneprovided by FlyBase
    Official Full Name
    anne boleynprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052000
    Locus tag
    Dmel_CG32000
    See related
    AllianceGenome:FB:FBgn0052000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATP13A2; BcDNA:LD05303; BcDNA:LD19039; BcDNA:SD17880; CG32000; dATP13A2; Dm V-1; Dmel\CG32000
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and organism. Used to study Kufor-Rakeb syndrome. Human ortholog(s) of this gene implicated in Kufor-Rakeb syndrome; Parkinson's disease; hereditary spastic paraplegia 78; and primary pulmonary hypertension. Orthologous to several human genes including ATP13A3 (ATPase 13A3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See anne in Genome Data Viewer
    Location:
    102A3-102A4; 4-0 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (132220..143123)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (152846..163749)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene pangolin Neighboring gene Ankyrin Neighboring gene long non-coding RNA:CR43956 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein. Dhanushkodi NR, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675288, Free PMC Article
    2. SON protects nascent transcripts from unproductive degradation by counteracting DIP1. Tay ML, et al. PLoS Genet, 2019 Nov. PMID 31730657, Free PMC Article
    3. ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysosome fusion. Wang R, et al. J Cell Biol, 2019 Jan 7. PMID 30538141, Free PMC Article
    4. Flies with Parkinson's disease. Vanhauwaert R, et al. Exp Neurol, 2015 Dec. PMID 25708988
    5. The Importance of Drosophila melanogaster Research to UnCover Cellular Pathways Underlying Parkinson's Disease. Vos M, et al. Cells, 2021 Mar 6. PMID 33800736, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant alpha-Synuclein.
      Title: ATP13A2 Gene Silencing in Drosophila Affects Autophagic Degradation of A53T Mutant α-Synuclein.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: 135593-135708 mobile_element_type = transposon:INE-1{}4649
    • Loc: 138906-138970 mobile_element_type = transposon:INE-1{}4651
    • Loc: 138971-139934 mobile_element_type = transposon:1360{}4770
    • Loc: 139426-139691 mobile_element_type = transposon:INE-1{}4653
    • Loc: 140103-140151 mobile_element_type = transposon:INE-1{}4655

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    anne boleyn
    Names
    CG32000-PA
    CG32000-PB
    CG32000-PC
    CG32000-PD
    CG32000-PE
    CG32000-PF
    CG32000-PG
    CG32000-PH
    CG32000-PI
    anne-PA
    anne-PB
    anne-PC
    anne-PD
    anne-PE
    anne-PF
    anne-PG
    anne-PH
    anne-PI
    anneboleyn

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      132220..143123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103379.2 → NP_001096849.1  anne boleyn, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ26
      Conserved Domains (5) summary
      TIGR01657
      Location:173 → 1355
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:381 → 621
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:158 → 291
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:758 → 813
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1087 → 1137
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_205865.2 → NP_995587.1  anne boleyn, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KQN3
      Conserved Domains (5) summary
      TIGR01657
      Location:110 → 1292
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:318 → 558
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:95 → 228
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:695 → 750
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:1024 → 1074
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. NM_166728.2 → NP_726532.1  anne boleyn, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXV3
      Related
      FBpp0088461
      Conserved Domains (2) summary
      pfam00122
      Location:381 → 621
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:158 → 291
      P5-ATPase; P5-type ATPase cation transporter

    4. NM_166733.2 → NP_726537.1  anne boleyn, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMA3
      Related
      FBpp0088460
      Conserved Domains (2) summary
      pfam00122
      Location:220 → 460
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:1 → 130
      P5-ATPase; P5-type ATPase cation transporter

    5. NM_166729.2 → NP_726533.1  anne boleyn, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMA7
      Related
      FBpp0088459
      Conserved Domains (2) summary
      pfam00122
      Location:318 → 558
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:95 → 228
      P5-ATPase; P5-type ATPase cation transporter

    6. NM_001272114.1 → NP_001259043.1  anne boleyn, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259043.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L0MLL1
      Conserved Domains (5) summary
      TIGR01657
      Location:12 → 1194
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:220 → 460
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:1 → 130
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:597 → 652
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:926 → 976
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. NM_166730.3 → NP_726534.2  anne boleyn, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726534.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMA6
      Related
      FBpp0088463
      Conserved Domains (5) summary
      TIGR01657
      Location:36 → 1218
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:244 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:21 → 154
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:621 → 676
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:950 → 1000
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    8. NM_166732.3 → NP_726536.2  anne boleyn, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726536.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMA6
      Related
      FBpp0088462
      Conserved Domains (5) summary
      TIGR01657
      Location:36 → 1218
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:244 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:21 → 154
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:621 → 676
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:950 → 1000
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    9. NM_166731.2 → NP_726535.1  anne boleyn, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMA5
      Related
      FBpp0088464
      Conserved Domains (2) summary
      pfam00122
      Location:244 → 484
      E1-E2_ATPase; E1-E2 ATPase
      pfam12409
      Location:21 → 154
      P5-ATPase; P5-type ATPase cation transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ26 A8DZ26
    L0MLL1 L0MLL1
    Q7KQN3 Q7KQN3
    Q8IG91 Q8IG91
    Q8IMA3 Q8IMA3
    Q8IMA5 Q8IMA5
    Q8IMA6 Q8IMA6
    Q8IMA7 Q8IMA7
    Q8SXV3 Q8SXV3
    Q8T0G2 Q8T0G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous