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    Octbeta1R Octopamine beta1 receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Octbeta1Rprovided by FlyBase
    Official Full Name
    Octopamine beta1 receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038980
    Locus tag
    Dmel_CG6919
    See related
    AllianceGenome:FB:FBgn0038980
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.67; anon-WO0170980.68; CG6919; DmCG6919; Dmel\CG6919; Dmoa2; DmOctbeta1R; DmOctBeta1R; oa2; Oa2; OA2; OctBeta1; octbeta1r; octbeta1R
    Summary
    Enables octopamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and negative regulation of synaptic assembly at neuromuscular junction. Located in plasma membrane. Is expressed in several structures, including antennal lobe commissural pioneer interneuron; brain; epithelial tube; octopaminergic neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; metabolic dysfunction-associated steatotic liver disease; and type 2 diabetes mellitus. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4) and ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Octbeta1R in Genome Data Viewer
    Location:
    94B1-94B2; 3-75 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22497215..22520078)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18322937..18345800)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene testis-enriched HMG-box-containing protein 1 Neighboring gene testis-enriched HMG-box-containing protein 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Visual Input into the Drosophila melanogaster Mushroom Body. Li J, et al. Cell Rep, 2020 Sep 15. PMID 32937130, Free PMC Article
    2. Transiently increasing cAMP levels selectively in hippocampal excitatory neurons during sleep deprivation prevents memory deficits caused by sleep loss. Havekes R, et al. J Neurosci, 2014 Nov 19. PMID 25411499, Free PMC Article
    3. The neurobiology and evolution of cannabinoid signalling. Elphick MR, et al. Philos Trans R Soc Lond B Biol Sci, 2001 Mar 29. PMID 11316486, Free PMC Article
    4. Starvation-Induced Depotentiation of Bitter Taste in Drosophila. LeDue EE, et al. Curr Biol, 2016 Nov 7. PMID 27720624
    5. A family of octopamine [corrected] receptors that specifically induce cyclic AMP production or Ca2+ release in Drosophila melanogaster. Balfanz S, et al. J Neurochem, 2005 Apr. PMID 15816867

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.
      Title: Concerted Actions of Octopamine and Dopamine Receptors Drive Olfactory Learning.
    2. Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
      Title: Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octopamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables octopamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    octopamine beta1 receptor
    Names
    CG6919-PA
    CG6919-PB
    CG6919-PC
    CG6919-PE
    Octbeta1R-PA
    Octbeta1R-PB
    Octbeta1R-PC
    Octbeta1R-PE
    octopamine receptor
    octopamine receptor 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22497215..22520078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275914.1 → NP_001262843.1  octopamine beta1 receptor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KHN2, Q2PDQ3, Q4LBC0, Q9VCZ3
      UniProtKB/TrEMBL
      G2J627
      Conserved Domains (2) summary
      pfam00001
      Location:124 → 404
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:112 → 231
      7tm_4; Olfactory receptor

    2. NM_001038975.3 → NP_001034064.1  octopamine beta1 receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034064.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G7H820
      Conserved Domains (1) summary
      cd15066
      Location:109 → 415
      7tmA_DmOct-betaAR-like; Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_142800.3 → NP_651057.1  octopamine beta1 receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4KHN2, Q2PDQ3, Q4LBC0, Q9VCZ3
      UniProtKB/TrEMBL
      G2J627
      Related
      FBpp0083653
      Conserved Domains (2) summary
      pfam00001
      Location:124 → 404
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:112 → 231
      7tm_4; Olfactory receptor

    4. NM_001170219.2 → NP_001163690.1  octopamine beta1 receptor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIT6, G7H820
      Conserved Domains (2) summary
      pfam00001
      Location:124 → 404
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:112 → 231
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIT6 E1JIT6
    Q9VCZ3.1 Q9VCZ3

    Gene LinkOut

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