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    Ced-12 Ced-12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34633, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ced-12provided by FlyBase
    Official Full Name
    Ced-12provided by FlyBase
    Primary source
    FLYBASE:FBgn0032409
    Locus tag
    Dmel_CG5336
    See related
    AllianceGenome:FB:FBgn0032409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ced-12; ced12; Ced12; CG5336; dced-12; dCed-12; dCED-12; Dced-12; dced12; dCed12; Dmel\CG5336; elmo; Elmo; ELMO
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including border follicle cell migration; imaginal disc fusion, thorax closure; and positive regulation of JNK cascade. Located in cytoplasm and nucleus. Is expressed in several structures, including adult brain cell body rind; adult head; follicle cell; ganglia; and muscle cell. Orthologous to several human genes including ELMO1 (engulfment and cell motility 1) and ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ced-12 in Genome Data Viewer
    Location:
    33C4-33C4; 2-46 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12097838..12100839)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12097838..12100839)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Peroxin 19 Neighboring gene uncharacterized protein Neighboring gene Methyltransferase 2 Neighboring gene patsas Neighboring gene Threonyl-tRNA synthetase Neighboring gene Rab6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular signaling of Dock family proteins in neural function. Miyamoto Y, et al. Cell Signal, 2010 Feb. PMID 19796679
    2. The ABC Transporter Eato Promotes Cell Clearance in the Drosophila melanogaster Ovary. Santoso CS, et al. G3 (Bethesda), 2018 Mar 2. PMID 29295819, Free PMC Article
    3. Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila. Shiratsuchi A, et al. J Biol Chem, 2012 Jun 22. PMID 22547074, Free PMC Article
    4. QTL mapping of natural variation reveals that the developmental regulator bruno reduces tolerance to P-element transposition in the Drosophila female germline. Kelleher ES, et al. PLoS Biol, 2018 Oct. PMID 30376574, Free PMC Article
    5. Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge. Biersmith B, et al. Genetics, 2015 Jun. PMID 25908317, Free PMC Article

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The complex ELMO-Sponge is subapically enriched and is required for subapical restriction of Canoe in early embryos. The localization dynamics of ELMO-Sponge suggests a patterning mechanism for positioning the subapical region adjacent to the apical region.
      Title: ELMO and Sponge specify subapical restriction of Canoe and formation of the subapical domain in early Drosophila embryos.
    2. Our results show that integrins function as upstream signals to mediate Dim7-Elmo enrichment to the muscle attachment sites .
      Title: Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.
    3. identified and characterized the role of Drosophila Sponge (Spg), the vertebrate DOCK3/DOCK4 counterpart as an ELMO-interacting protein
      Title: The DOCK protein sponge binds to ELMO and functions in Drosophila embryonic CNS development.
    4. Overexpression of MBC and ELMO in the embryonic mesoderm causes defects in myoblast fusion reminiscent of those seen with constitutively-activated Rac1
      Title: Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle attachment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ced-12
    Names
    CG5336-PA
    Ced-12-PA
    elmo
    engulfment and cell motility

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12097838..12100839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135704.3 → NP_609548.1  Ced-12 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS15, Q9VKB2
      Related
      FBpp0079912
      Conserved Domains (3) summary
      cd13359
      Location:546 → 673
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:296 → 474
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:122 → 275
      DUF3361; Domain of unknown function (DUF3361)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS15 Q8MS15
    Q9VKB2 Q9VKB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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