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    Cln7 Cln7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38813, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cln7provided by FlyBase
    Official Full Name
    Cln7provided by FlyBase
    Primary source
    FLYBASE:FBgn0035767
    Locus tag
    Dmel_CG8596
    See related
    AllianceGenome:FB:FBgn0035767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8596; cln7; CLN7; Dmel\CG8596
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in postsynaptic density membrane. Is expressed in adult head; plasmatocyte primordium; and ventral epidermis primordium. Used to study neuronal ceroid lipofuscinosis 7. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 7. Orthologous to human MFSD8 (major facilitator superfamily domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cln7 in Genome Data Viewer
    Location:
    65F5-65F5; 3-20 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7341884..7345183, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7334984..7338283, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene wurmchen 1 Neighboring gene wurmchen 2 Neighboring gene Establishment of cohesion Neighboring gene lark Neighboring gene uncharacterized protein Neighboring gene Signal recognition particle 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels. Mohammed A, et al. Neurobiol Dis, 2017 Jul. PMID 28365214, Free PMC Article
    2. Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease. Jones MA, et al. Biol Open, 2014 Apr 4. PMID 24705017, Free PMC Article
    3. The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development. Connolly KJ, et al. Sci Rep, 2019 Oct 30. PMID 31666534, Free PMC Article
    4. Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 32733888, Free PMC Article
    5. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLN7 (and CLN3) are predominantly expressed in the glia that form the insect blood-brain-barrier.
      Title: in vivo localization of the neuronal ceroid lipofuscinosis proteins, CLN3 and CLN7, at endogenous expression levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cln7
    Names
    CG8596-PA
    CG8596-PB
    CG8596-PC
    Cln7-PA
    Cln7-PB
    Cln7-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7341884..7345183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139850.4 → NP_648107.3  Cln7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648107.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0M3, Q9VS51
      Related
      FBpp0076591
      Conserved Domains (2) summary
      cd06174
      Location:37 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 449
      MFS_1; Major Facilitator Superfamily

    2. NM_001274580.1 → NP_001261509.1  Cln7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0M3, Q9VS51
      Conserved Domains (2) summary
      cd06174
      Location:37 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 449
      MFS_1; Major Facilitator Superfamily

    3. NM_001274579.1 → NP_001261508.1  Cln7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0M3, Q9VS51
      Conserved Domains (2) summary
      cd06174
      Location:37 → 479
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:40 → 449
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS51 Q9VS51

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