ph-d polyhomeotic distal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ph-dprovided by FlyBase
Official Full Name: polyhomeotic distalprovided by FlyBase
Primary source: FLYBASE:FBgn0004860
Locus tag: Dmel_CG3895
See related: AllianceGenome:FB:FBgn0004860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3895; Dmel\CG3895; DROZFP; EG:BACN25G24.3; ph; Ph; PH; ph-D; Ph-d; PH-d; phd; PhD; PHD; phm; ph[d]; ph[D]
Summary: Enables chromatin binding activity and protein-folding chaperone binding activity. Involved in negative regulation of DNA-templated transcription and syncytial blastoderm mitotic cell cycle. Located in nucleolus and polytene chromosome. Part of PRC1 complex. Is expressed in several structures, including cell body; embryonic/larval salivary gland; germline cell; imaginal disc; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to several human genes including PHC1 (polyhomeotic homolog 1) and PHC3 (polyhomeotic homolog 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2115727..2123286, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2009760..2017319, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

Names: CG3895-PA; CG3895-PB; ph-d-PA; ph-d-PB; polyhomeotic; polyhomeotic proximal; polyhomeotic-distal

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