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    Pgm2a Phosphoglucomutase 2a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgm2aprovided by FlyBase
    Official Full Name
    Phosphoglucomutase 2aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033377
    Locus tag
    Dmel_CG8073
    See related
    AllianceGenome:FB:FBgn0033377
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8073; Dmel\CG8073; Pmm45A
    Summary
    Predicted to enable phosphopentomutase activity. Predicted to be involved in purine ribonucleoside salvage. Is expressed in spermatozoon. Orthologous to human PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgm2a in Genome Data Viewer
    Location:
    45A6-45A7; 2-60 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9107151..9109718, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4994656..4997223, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Van Gogh Neighboring gene Mystery 45A Neighboring gene tsunagi Neighboring gene Phosphorylated adaptor for RNA export

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Dar GH, et al. Nat Commun, 2021 Nov 18. PMID 34795295, Free PMC Article
    2. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Mohr SE, et al. Genes Dev, 2001 Nov 1. PMID 11691839, Free PMC Article
    3. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Upadhyay A, et al. Mol Neurodegener, 2023 Sep 14. PMID 37710351, Free PMC Article
    4. Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2. White-Grindley E, et al. PLoS Biol, 2014 Feb. PMID 24523662, Free PMC Article
    5. Characteristics of genes up-regulated and down-regulated after 24 h starvation in the head of Drosophila. Fujikawa K, et al. Gene, 2009 Oct 1. PMID 19573582

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopentomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoglucomutase 2a
    Names
    CG8073-PA
    Pgm2a-PA
    phosphomannomutase 45A
    NP_610453.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9107151..9109718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136609.5 → NP_610453.1  phosphoglucomutase 2a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7P1, Q95X10
      Related
      FBpp0087711
      Conserved Domains (2) summary
      cd05799
      Location:62 → 604
      PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...
      PTZ00150
      Location:23 → 623
      PTZ00150; phosphoglucomutase-2-like protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7P1 A1Z7P1
    Q5BHU7 Q5BHU7
    Q86NU8 Q86NU8
    Q95RR7 Q95RR7
    Q95X10 Q95X10

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