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    CG14034 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33751, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG14034provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250847
    Locus tag
    Dmel_CG14034
    See related
    AllianceGenome:FB:FBgn0250847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-SAGE:Wang-122; Dmel\CG14034
    Summary
    Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14034 in Genome Data Viewer
    Location:
    25D1-25D1; 2-16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5215189..5216542, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5215189..5216542, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 28d2 Neighboring gene Cytochrome P450 28d1 Neighboring gene uncharacterized protein Neighboring gene Troponin C at 25D Neighboring gene thickveins Neighboring gene transfer RNA:Aspartic acid-GTC 2-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orthology, function and evolution of accessory gland proteins in the Drosophila repleta group. Almeida FC, et al. Genetics, 2009 Jan. PMID 19015541, Free PMC Article
    2. Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila. Swanson WJ, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11404480, Free PMC Article
    3. Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. Findlay GD, et al. PLoS Genet, 2014 Jan. PMID 24453993, Free PMC Article
    4. Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Mueller JL, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15345744, Free PMC Article
    5. Postmating transcriptional changes in reproductive tracts of con- and heterospecifically mated Drosophila mojavensis females. Bono JM, et al. Proc Natl Acad Sci U S A, 2011 May 10. PMID 21518862, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables lipase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14034-PB
    CG14034-PC
    anon-SAGE:Wang-122

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5215189..5216542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298689.1 → NP_001285618.1  uncharacterized protein Dmel_CG14034, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8T1, Q3HKQ5
      Conserved Domains (1) summary
      cd00707
      Location:37 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    2. NM_001042874.2 → NP_001036339.1  uncharacterized protein Dmel_CG14034, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8T1, Q3HKQ5
      Conserved Domains (1) summary
      cd00707
      Location:37 → 303
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8T1 Q0E8T1

    Gene LinkOut

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