U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dbr debra [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33161, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dbrprovided by FlyBase
    Official Full Name
    debraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0067779
    Locus tag
    Dmel_CG11371
    See related
    AllianceGenome:FB:FBgn0067779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD26519; CG11371; Dbr; Debra; Dmel\CG11371; EP0456; EP456
    Summary
    Predicted to enable zinc ion binding activity. Involved in long-term memory. Located in multivesicular body. Is expressed in several structures, including Kenyon cell; adult brain; cuboidal/columnar epithelium; embryonic/larval dorsal vessel; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dbr in Genome Data Viewer
    Location:
    21B1-21B1; 2-0.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (66482..71390)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (66482..71390)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chitin deacetylase-like 5 Neighboring gene long non-coding RNA:CR46254 Neighboring gene long non-coding RNA:CR45339 Neighboring gene long non-coding RNA:CR45340 Neighboring gene antisense RNA:CR44987 Neighboring gene galectin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Debra, a protein mediating lysosomal degradation, is required for long-term memory in Drosophila. Kottler B, et al. PLoS One, 2011. PMID 21991383, Free PMC Article
    2. Early development of the Drosophila mushroom bodies, brain centres for associative learning and memory. Tettamanti M, et al. Dev Genes Evol, 1997 Oct. PMID 27747422
    3. Green fluorescent protein as a vital marker and reporter of gene expression in Drosophila. Yeh E, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624365, Free PMC Article
    4. Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. Fernandes C, et al. Mol Brain, 2011 Apr 19. PMID 21504582, Free PMC Article
    5. A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci. Dai P, et al. Dev Cell, 2003 Jun. PMID 12791275

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. debra encodes a protein involved in the Hedgehog signaling pathway as a mediator of protein degradation by the lysosome.
      Title: Debra, a protein mediating lysosomal degradation, is required for long-term memory in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    debra
    Names
    CG11371-PB
    CG11371-PC
    CG11371-PD
    CG11371-PE
    CG11371-PF
    dbr-PB
    dbr-PC
    dbr-PD
    dbr-PE
    dbr-PF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      66482..71390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258883.3 → NP_001245812.1  debra, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V474
      Conserved Domains (1) summary
      smart00868
      Location:8 → 84
      zf-AD; Zinc-finger associated domain (zf-AD)

    2. NM_134642.3 → NP_608486.1  debra, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608486.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V474
      Related
      FBpp0077759
      Conserved Domains (1) summary
      smart00868
      Location:8 → 84
      zf-AD; Zinc-finger associated domain (zf-AD)

    3. NM_001258881.2 → NP_001245810.1  debra, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V474
      Conserved Domains (1) summary
      smart00868
      Location:8 → 84
      zf-AD; Zinc-finger associated domain (zf-AD)

    4. NM_001258880.2 → NP_001245809.1  debra, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V474
      Conserved Domains (1) summary
      smart00868
      Location:8 → 84
      zf-AD; Zinc-finger associated domain (zf-AD)

    5. NM_001258882.2 → NP_001245811.1  debra, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V474
      Conserved Domains (1) summary
      smart00868
      Location:8 → 84
      zf-AD; Zinc-finger associated domain (zf-AD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961T5 Q961T5
    Q9V474 Q9V474

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools