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    l(3)80Fj lethal (3) 80Fj [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)80Fjprovided by FlyBase
    Official Full Name
    lethal (3) 80Fjprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287182
    Locus tag
    Dmel_CG17514
    See related
    AllianceGenome:FB:FBgn0287182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    80Fj; CG17514; Dmel\CG17514; l(3)Lh1; l1; lethal 1
    Summary
    Predicted to enable protein kinase regulator activity. Predicted to be involved in cellular response to amino acid starvation and regulation of translation. Predicted to be active in cytosol. Is expressed in adult head and spermatozoon. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)80Fj in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (27967244..28012599, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (2775853..2821208)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46250 Neighboring gene Dead box protein 80 Neighboring gene long non-coding RNA:CR46482 Neighboring gene pseudo Neighboring gene eukaryotic translation initiation factor 4B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster. Schulze SR, et al. Genetics, 2005 Apr. PMID 15687284, Free PMC Article
    2. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. Lin CH, et al. PLoS One, 2012. PMID 22761891, Free PMC Article
    3. Genetic Analysis of the Heterochromatin of Chromosome 3 in Drosophila Melanogaster. II. Vital Loci Identified through Ems Mutagenesis. Marchant GE, et al. Genetics, 1988 Oct. PMID 17246481, Free PMC Article
    4. Cytogenetic analysis of the third chromosome heterochromatin of Drosophila melanogaster. Koryakov DE, et al. Genetics, 2002 Feb. PMID 11861557, Free PMC Article
    5. Essential genes in proximal 3L heterochromatin of Drosophila melanogaster. Schulze S, et al. Mol Gen Genet, 2001 Feb. PMID 11254125

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lethal (3) 80Fj
    Names
    CG17514-PA
    CG17514-PG
    l(3)80Fj-PA
    l(3)80Fj-PG
    lethal 1
    lethal1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      27967244..28012599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015316.3 → NP_001015316.1  lethal (3) 80Fj, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7PLL6
      Conserved Domains (5) summary
      pfam12074
      Location:379 → 685
      DUF3554; Domain of unknown function (DUF3554)
      pfam13001
      Location:1421 → 1669
      Ecm29; Proteasome stabilizer
      pfam13513
      Location:1903 → 1948
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:1574 → 1679
      HEAT_2; HEAT repeats
      sd00044
      Location:1881 → 1909
      HEAT; HEAT repeat [structural motif]

    2. NM_001170371.2 → NP_001163842.2  lethal (3) 80Fj, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163842.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2A6J9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D2A6J9 D2A6J9
    Q5BIL6 Q5BIL6
    Q6JE78 Q6JE78
    Q6JE80 Q6JE80
    Q6JE81 Q6JE81
    Q7PLL6 Q7PLL6

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