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    AspRS Aspartyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AspRSprovided by FlyBase
    Official Full Name
    Aspartyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002069
    Locus tag
    Dmel_CG3821
    See related
    AllianceGenome:FB:FBgn0002069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aaRS(Asp); aats-asp; Aats-asp; Aats-Asp; anon-EST:Liang-2.49; cDNA1; CG3821; clone 2.49; DARS; Dmel\CG3821; DRS; l(2)49Db; l(2)k04508; l(2)v27; l(2)vr1; poney; vr1
    Summary
    Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head; adult heart; embryonic/larval salivary gland; and organism. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AspRS in Genome Data Viewer
    Location:
    49D6-49D7; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12877004..12883168)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8764509..8770673)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43469 Neighboring gene antisense RNA:CR43468 Neighboring gene Beta-alanine transporter Neighboring gene Lifeguard Neighboring gene N-methyl-D-aspartate receptor-associated protein Neighboring gene antisense RNA:CR45141 Neighboring gene vestigial Neighboring gene long non-coding RNA:CR46237

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*. Markesich DC, et al. Development, 2000 Feb. PMID 10631177
    2. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
    3. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    4. Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal. Stitzinger SM, et al. Mol Gen Genet, 1999 Feb. PMID 10071220
    5. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Harbison ST, et al. Nat Genet, 2009 Mar. PMID 19234472, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Aspartyl-tRNA synthetase
    Names
    AspRS-PA
    AspRS-PB
    AspRS-PC
    CG3821-PA
    CG3821-PB
    CG3821-PC
    lethal(2)49Db
    NP_001260930.1
    NP_001260931.1
    NP_476609.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12877004..12883168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274002.2 → NP_001260931.1  Aspartyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

    2. NM_057261.4 → NP_476609.1  Aspartyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Related
      FBpp0086897
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...

    3. NM_001274001.1 → NP_001260930.1  Aspartyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K0E6 Q7K0E6
    Q9XYM1 Q9XYM1

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