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    Pabp2 Pabp2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pabp2provided by FlyBase
    Official Full Name
    Pabp2provided by FlyBase
    Primary source
    FLYBASE:FBgn0005648
    Locus tag
    Dmel_CG2163
    See related
    AllianceGenome:FB:FBgn0005648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2163; Dmel\CG2163; dpabII; pabp2; pAbp2; PABP2; PABPN1; rox2; Rox2; ROX2
    Summary
    Enables poly(A) binding activity. Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and nuclear-transcribed mRNA poly(A) tail shortening. Located in cytosol and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; follicle cell; germline cell; and ovary. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pabp2 in Genome Data Viewer
    Location:
    44B3-44B3; 2-58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8131431..8134374)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4018936..4021879)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 50kD Neighboring gene coilin Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Odorant-binding protein 44a Neighboring gene Lipin Neighboring gene kermit Neighboring gene long non-coding RNA:CR44068 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitro. Benoit B, et al. Nucleic Acids Res, 1999 Oct 1. PMID 10481015, Free PMC Article
    2. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
    3. Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Clements J, et al. Dev Biol, 2009 Oct 15. PMID 19666017, Free PMC Article
    4. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Chou CC, et al. Hum Mol Genet, 2015 Sep 15. PMID 26130692, Free PMC Article
    5. Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila. Sysoev VO, et al. Nat Commun, 2016 Jul 5. PMID 27378189, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1. We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy.
      Title: Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis.
    2. Results suggest that oculopharyngeal muscular dystrophy does not result from polyalanine toxicity, but from an intrinsic
      Title: A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1.
    3. Results identify the poly(A) binding protein PABP2 as a regulator of maternal mRNA poly(A) tail length and highlight the importance of this mode of translational control.
      Title: An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Pabp2
    Names
    CG2163-PA
    CG2163-PB
    Pabp2-PA
    Pabp2-PB
    nuclear poly(A)-binding protein
    poly-A binding protein 2
    polyA-binding protein II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8131431..8134374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057554.4 → NP_476902.1  Pabp2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7B1, Q27926, Q7JQ60, Q7KNF2
      UniProtKB/TrEMBL
      E2QC83
      Related
      FBpp0087863
      Conserved Domains (2) summary
      COG0724
      Location:43 → 172
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:97 → 172
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

    2. NM_165589.3 → NP_724648.1  Pabp2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724648.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z7B1, Q27926, Q7JQ60, Q7KNF2
      UniProtKB/TrEMBL
      E2QC83
      Related
      FBpp0087864
      Conserved Domains (2) summary
      COG0724
      Location:43 → 172
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12550
      Location:97 → 172
      RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QC83 E2QC83
    Q7KNF2.1 Q7KNF2

    Gene LinkOut

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