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    Acbp3 Acyl-CoA binding protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38783, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Acbp3provided by FlyBase
    Official Full Name
    Acyl-CoA binding protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0250836
    Locus tag
    Dmel_CG8628
    See related
    AllianceGenome:FB:FBgn0250836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACBP; anon-SAGE:Wang-073; CG8628; DmCG8628; Dmel\CG8628
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ACBD7 (acyl-CoA binding domain containing 7) and DBI (diazepam binding inhibitor, acyl-CoA binding protein). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Acbp3 in Genome Data Viewer
    Location:
    65E4-65E4; 3-19 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7130874..7131505)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7123974..7124605)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene Acyl-CoA binding protein 4 Neighboring gene Acyl-CoA binding protein 6 Neighboring gene Acyl-CoA binding protein 2 Neighboring gene melted Neighboring gene cornetto

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Kors S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Dec. PMID 39271061
    2. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070
    3. The microbiome stabilizes circadian rhythms in the gut. Zhang Y, et al. Proc Natl Acad Sci U S A, 2023 Jan 31. PMID 36689661, Free PMC Article
    4. Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila. Ullastres A, et al. Genome Biol, 2021 Sep 14. PMID 34521452, Free PMC Article
    5. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA binding protein 3
    Names
    Acbp3-PA
    Acbp3-PB
    CG8628-PA
    CG8628-PB
    acyl-CoA-binding protein
    anon-SAGE:Wang-073

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7130874..7131505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139826.3 → NP_648083.1  Acyl-CoA binding protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3LF68, Q9VS22
      Related
      FBpp0076623
      Conserved Domains (1) summary
      cl00221
      Location:4 → 84
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. NM_001169895.1 → NP_001163366.1  Acyl-CoA binding protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3LF68, Q9VS22
      Conserved Domains (1) summary
      cl00221
      Location:4 → 84
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS22 Q9VS22

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