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    Dyb Dystrobrevin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dybprovided by FlyBase
    Official Full Name
    Dystrobrevinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033739
    Locus tag
    Dmel_CG8529
    See related
    AllianceGenome:FB:FBgn0033739
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8529; DmDYB; Dmel\CG8529
    Summary
    Predicted to be a structural constituent of muscle. Involved in maintenance of presynaptic active zone structure and regulation of neurotransmitter secretion. Located in neuromuscular junction. Is expressed in several structures, including adult head; embryonic epidermis; embryonic/larval midgut primordium; ganglia; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in cardiomyopathy and left ventricular noncompaction. Orthologous to several human genes including DTNA (dystrobrevin alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dyb in Genome Data Viewer
    Location:
    49A6-49A6; 2-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12437345..12452916)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8324850..8340421)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein Neighboring gene Deubiquitinating apoptotic inhibitor Neighboring gene Transmembrane protein 18 Neighboring gene uncharacterized protein Neighboring gene Lachesin Neighboring gene dim gamma-tubulin 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epidemiology and genetics of Meniere's disease. Lopez-Escamez JA, et al. Curr Opin Neurol, 2024 Feb 1. PMID 37865853
    2. A Drosophila model for Meniere's disease: Dystrobrevin is required for support cell function in hearing and proprioception. Requena T, et al. Front Cell Dev Biol, 2022. PMID 36438562, Free PMC Article
    3. Conservation of components of the dystrophin complex in Drosophila. Greener MJ, et al. FEBS Lett, 2000 Sep 29. PMID 11018515
    4. Embryonic expression patterns of the Drosophila dystrophin-associated glycoprotein complex orthologs. Dekkers LC, et al. Gene Expr Patterns, 2004 Mar. PMID 15161095
    5. The roles of the dystrophin-associated glycoprotein complex at the synapse. Pilgram GS, et al. Mol Neurobiol, 2010 Feb. PMID 19899002, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 12446465-12446517 mobile_element_type = transposon:G5A{}4969

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of presynaptic active zone structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of dystrophin-associated glycoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dystrobrevin
    Names
    CG8529-PA
    CG8529-PC
    CG8529-PD
    CG8529-PF
    CG8529-PG
    CG8529-PH
    CG8529-PI
    Dyb-PA
    Dyb-PC
    Dyb-PD
    Dyb-PF
    Dyb-PG
    Dyb-PH
    Dyb-PI
    Dystrobrevin-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12437345..12452916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032237.3 → NP_001027408.1  dystrobrevin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z906, Q9GT70
      Conserved Domains (4) summary
      cd02334
      Location:232 → 280
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:436 → 482
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:7 → 131
      EF-hand_2; EF hand
      pfam09069
      Location:135 → 223
      EF-hand_3; EF-hand

    2. NM_165904.3 → NP_725171.1  dystrobrevin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9B2, Q9GT70
      Related
      FBpp0087040
      Conserved Domains (4) summary
      cd02334
      Location:232 → 280
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:436 → 482
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:7 → 131
      EF-hand_2; EF hand
      pfam09069
      Location:135 → 223
      EF-hand_3; EF-hand

    3. NM_001032236.3 → NP_001027407.2  dystrobrevin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027407.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z907, Q9GT70
      Conserved Domains (4) summary
      cd02334
      Location:232 → 280
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:436 → 482
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:7 → 131
      EF-hand_2; EF hand
      pfam09069
      Location:135 → 223
      EF-hand_3; EF-hand

    4. NM_078988.4 → NP_523712.3  dystrobrevin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523712.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      E2QCB7, Q9GT70
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:445 → 491
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand

    5. NM_165905.4 → NP_725172.2  dystrobrevin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725172.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z904, Q9GT70
      Related
      FBpp0087041
      Conserved Domains (4) summary
      cd02334
      Location:241 → 289
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam06005
      Location:446 → 522
      DUF904; Protein of unknown function (DUF904)
      pfam09068
      Location:16 → 140
      EF-hand_2; EF hand
      pfam09069
      Location:144 → 232
      EF-hand_3; EF-hand

    6. NM_001103817.2 → NP_001097287.1  dystrobrevin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097287.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYB7
      Conserved Domains (4) summary
      cd02334
      Location:232 → 280
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:436 → 482
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:7 → 131
      EF-hand_2; EF hand
      pfam09069
      Location:135 → 223
      EF-hand_3; EF-hand

    7. NM_001259351.2 → NP_001246280.1  dystrobrevin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246280.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6Z2, Q9GT70
      Conserved Domains (4) summary
      cd02334
      Location:232 → 280
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam00831
      Location:436 → 482
      Ribosomal_L29; Ribosomal L29 protein
      pfam09068
      Location:7 → 131
      EF-hand_2; EF hand
      pfam09069
      Location:135 → 223
      EF-hand_3; EF-hand
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6Z2 A0A0B4K6Z2
    A1Z904 A1Z904
    A1Z906 A1Z906
    A1Z907 A1Z907
    A8DYB7 A8DYB7
    E2QCB7 E2QCB7
    Q0E9B2 Q0E9B2
    Q95SU4 Q95SU4
    Q9GT70 Q9GT70

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