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    Tsp5D Tetraspanin 5D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp5Dprovided by FlyBase
    Official Full Name
    Tetraspanin 5Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029837
    Locus tag
    Dmel_CG4690
    See related
    AllianceGenome:FB:FBgn0029837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4690; Dm.Tsp5D; Dmel\CG4690; tsp5D
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Orthologous to several human genes including TSPAN4 (tetraspanin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp5D in Genome Data Viewer
    Location:
    5D3-5D3; 1-15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6069131..6074857, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5963164..5968890, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. Shulman JM, et al. Am J Hum Genet, 2011 Feb 11. PMID 21295279, Free PMC Article
    2. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    3. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
    4. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
    5. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 5D
    Names
    CG4690-PA
    CG4690-PB
    CG4690-PC
    Tsp5D-PA
    Tsp5D-PB
    Tsp5D-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6069131..6074857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078499.5 → NP_511054.4  tetraspanin 5D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511054.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS10, Q9W441
      Conserved Domains (1) summary
      pfam00335
      Location:9 → 252
      Tetraspannin; Tetraspanin family

    2. NM_001144691.2 → NP_001138163.1  tetraspanin 5D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138163.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MS10, Q9W441
      Conserved Domains (1) summary
      pfam00335
      Location:9 → 252
      Tetraspannin; Tetraspanin family

    3. NM_001272337.1 → NP_001259266.1  tetraspanin 5D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDV2, Q8MS10
      Conserved Domains (2) summary
      cd03165
      Location:105 → 228
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:8 → 256
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDV2 M9PDV2
    Q8MS10 Q8MS10
    Q9W441 Q9W441

    Gene LinkOut

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