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    CG8665 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35407, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG8665provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032945
    Locus tag
    Dmel_CG8665
    See related
    AllianceGenome:FB:FBgn0032945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8665
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; amnioserosa; embryonic/larval crystal cell; embryonic/larval fat body; and embryonic/larval midgut. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1) and ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8665 in Genome Data Viewer
    Location:
    39D2-39D2; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21371227..21377995)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21371227..21377995)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene defective transmitter release Neighboring gene Gustatory receptor 39b Neighboring gene nervana 3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization. Krupenko NI, et al. Chem Biol Interact, 2015 Jun 5. PMID 25549576, Free PMC Article
    2. Positive selection near an inversion breakpoint on the neo-X chromosome of Drosophila americana. Evans AL, et al. Genetics, 2007 Nov. PMID 17660565, Free PMC Article
    3. Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster. Wilinski D, et al. Nat Commun, 2019 Sep 6. PMID 31492856, Free PMC Article
    4. The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila. Abramov YA, et al. Genetics, 2016 Jan. PMID 26500261, Free PMC Article
    5. Drosophila glia: Few cell types and many conserved functions. Yildirim K, et al. Glia, 2019 Jan. PMID 30443934

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21372669-21372950 mobile_element_type = transposon:Tc3{}4191
    • Loc: 21377803-21377949 mobile_element_type = transposon:INE-1{}4119

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formyltetrahydrofolate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formyltetrahydrofolate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8665-PA
    NP_610107.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21371227..21377995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136263.2 → NP_610107.1  uncharacterized protein Dmel_CG8665 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNU7, Q9VIC9
      Related
      FBpp0081045
      Conserved Domains (6) summary
      cd07140
      Location:428 → 913
      ALDH_F1L_FTFDH; 10-formyltetrahydrofolate dehydrogenase, ALDH family 1L
      cd08703
      Location:212 → 316
      FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
      PLN02466
      Location:396 → 909
      PLN02466; aldehyde dehydrogenase family 2 member
      COG0223
      Location:4 → 315
      Fmt; Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]
      pfam00550
      Location:338 → 403
      PP-binding; Phosphopantetheine attachment site
      cl00395
      Location:5 → 207
      FMT_core; Formyltransferase, catalytic core domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIC9 Q9VIC9

    Gene LinkOut

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