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    sfl sulfateless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sflprovided by FlyBase
    Official Full Name
    sulfatelessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020251
    Locus tag
    Dmel_CG8339
    See related
    AllianceGenome:FB:FBgn0020251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8339; CT24567; Dmel\CG8339; dw; l(3)03844; lincRNA.S4253; Ndst; NDST; Sfl; SFL
    Summary
    Enables sulfotransferase activity. Involved in several processes, including epithelial cell migration, open tracheal system; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and imaginal disc-derived wing morphogenesis. Acts upstream of with a positive effect on fibroblast growth factor receptor signaling pathway. Located in Golgi cis cisterna and endoplasmic reticulum. Is expressed in adult head; embryonic/larval antennal lobe glomerulus; larval mushroom body calyx glomerulus; organism; and projection neurons. Used to study autism spectrum disorder; azoospermia; and intellectual disability. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sfl in Genome Data Viewer
    Location:
    65B3-65B4; 3-17 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6495680..6550104)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6488780..6543204)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene bulli Neighboring gene long non-coding RNA:CR45979 Neighboring gene Vacuolar protein sorting 8 Neighboring gene long non-coding RNA:CR46500 Neighboring gene beta-Tubulin at 65B Neighboring gene Mitochondrial calcium uniporter Neighboring gene javelin Neighboring gene nudel

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo activities of heparan sulfate differentially modified by NDSTs during development. Nakato E, et al. Proteoglycan Res, 2024 Jan 1. PMID 38616954, Free PMC Article
    2. Emerging functions of circular RNA in aging. Kim E, et al. Trends Genet, 2021 Sep. PMID 34016449
    3. Loss of heparan sulfate in the niche leads to tumor-like germ cell growth in the Drosophila testis. Levings DC, et al. Glycobiology, 2018 Dec 1. PMID 29069438, Free PMC Article
    4. Circular RNA Involvement in Aging and Longevity. Niu R, et al. Curr Genomics, 2022 Nov 18. PMID 36778190, Free PMC Article
    5. Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient. Gude F, et al. Nat Commun, 2023 Feb 10. PMID 36765094, Free PMC Article

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [heparan sulfate]-glucosamine N-sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate N-deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in epithelial cell migration, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosaminoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cis cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfateless
    Names
    CG8339-PA
    CG8339-PB
    CG8339-PC
    CG8339-PD
    HS N-deacetylase/N-sulfotransferase
    diet-wingless
    sfl-PA
    sfl-PB
    sfl-PC
    sfl-PD
    NP_001163354.1
    NP_001401031.1
    NP_001401032.1
    NP_523946.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6495680..6550104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079222.5 → NP_523946.1  sulfateless, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3L1
      UniProtKB/TrEMBL
      E1JID8
      Related
      FBpp0076677
      Conserved Domains (2) summary
      pfam00685
      Location:758 → 1017
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:179 → 669
      HSNSD; heparan sulfate-N-deacetylase

    2. NM_001414148.1 → NP_001401031.1  sulfateless, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0Y2

    3. NM_001169883.3 → NP_001163354.1  sulfateless, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163354.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3L1
      UniProtKB/TrEMBL
      E1JID8
      Conserved Domains (2) summary
      pfam00685
      Location:758 → 1017
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:179 → 669
      HSNSD; heparan sulfate-N-deacetylase

    4. NM_001414149.1 → NP_001401032.1  sulfateless, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3Y9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JID8 E1JID8
    Q9V3L1.1 Q9V3L1

    Gene LinkOut

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