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    NC2beta Negative Cofactor 2beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NC2betaprovided by FlyBase
    Official Full Name
    Negative Cofactor 2betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028926
    Locus tag
    Dmel_CG4185
    See related
    AllianceGenome:FB:FBgn0028926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS00929.3; CG4185; dDr1; Dmel\CG4185; dNC2; dNC2beta; Dr1; NC2 beta; Nc2b
    Summary
    Enables DNA-binding transcription factor binding activity and core promoter sequence-specific DNA binding activity. Involved in chromatin remodeling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of ATAC complex. Is expressed in several structures, including embryonic dorsal epidermis; embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; and ganglia. Orthologous to human DR1 (down-regulator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NC2beta in Genome Data Viewer
    Location:
    35B8-35B8; 2-50 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15007813..15008538)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15007813..15008538)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene moladietz Neighboring gene Dynactin 5, p25 subunit Neighboring gene Ankrd49 Neighboring gene long non-coding RNA:CR43856 Neighboring gene tRNA-histidine guanylyltransferase Neighboring gene RNA guanine-7 methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A basal transcription factor that activates or represses transcription. Willy PJ, et al. Science, 2000 Nov 3. PMID 11062130
    2. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
    3. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
    4. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Suganuma T, et al. Cell, 2010 Sep 3. PMID 20813260
    5. The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling. Khan SJ, et al. PLoS Genet, 2017 Jul. PMID 28753614, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of negative cofactor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of negative cofactor 2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    negative cofactor 2beta
    Names
    CG4185-PA
    NC2beta-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15007813..15008538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135892.4 → NP_609736.1  negative cofactor 2beta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609736.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2XYD4, Q9NKA2, Q9VJQ5
      Related
      FBpp0080256
      Conserved Domains (1) summary
      cl23735
      Location:15 → 135
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJQ5.1 Q9VJQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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