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    kek5 kekkon 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek5provided by FlyBase
    Official Full Name
    kekkon 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0031016
    Locus tag
    Dmel_CG12199
    See related
    AllianceGenome:FB:FBgn0031016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12199; CT10486; Dmel\CG12199; kek-5; Kek5
    Summary
    Involved in negative regulation of BMP signaling pathway. Located in plasma membrane. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; gut section; imaginal disc; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek5 in Genome Data Viewer
    Location:
    18C3-18C7; 1-62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19353181..19471914)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19247214..19365947)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene nicotinic Acetylcholine Receptor alpha7 Neighboring gene outsiders Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 15/16 Neighboring gene narya Neighboring gene mitochondrial ribosomal protein S14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
    2. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    3. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article
    4. Kekkon5 is an extracellular regulator of BMP signaling. Evans TA, et al. Dev Biol, 2009 Feb 1. PMID 19013143
    5. Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. Ulian-Benitez S, et al. PLoS Genet, 2017 Aug. PMID 28846707, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 5
    Names
    CG12199-PA
    CG12199-PB
    CG12199-PC
    CG12199-PD
    kek5-PA
    kek5-PB
    kek5-PC
    kek5-PD
    kekkon-like
    kekkon5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19353181..19471914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258817.2 → NP_001245746.1  kekkon 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PM1, Q9VWI6
      Conserved Domains (6) summary
      cd00096
      Location:296 → 376
      Ig; Immunoglobulin domain
      smart00370
      Location:122 → 145
      LRR; Leucine-rich repeats, outliers
      smart00082
      Location:229 → 277
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:76 → 160
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat

    2. NM_167648.3 → NP_728243.1  kekkon 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PM1, Q9VWI6
      Related
      FBpp0301162
      Conserved Domains (6) summary
      cd00096
      Location:296 → 376
      Ig; Immunoglobulin domain
      smart00370
      Location:122 → 145
      LRR; Leucine-rich repeats, outliers
      smart00082
      Location:229 → 277
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:76 → 160
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat

    3. NM_167647.3 → NP_728242.1  kekkon 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PM1, Q9VWI6
      Related
      FBpp0074476
      Conserved Domains (6) summary
      cd00096
      Location:296 → 376
      Ig; Immunoglobulin domain
      smart00370
      Location:122 → 145
      LRR; Leucine-rich repeats, outliers
      smart00082
      Location:229 → 277
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:76 → 160
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat

    4. NM_133154.5 → NP_573382.1  kekkon 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PM1, Q9VWI6
      Related
      FBpp0074477
      Conserved Domains (6) summary
      cd00096
      Location:296 → 376
      Ig; Immunoglobulin domain
      smart00370
      Location:122 → 145
      LRR; Leucine-rich repeats, outliers
      smart00082
      Location:229 → 277
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:76 → 160
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:99 → 159
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PM1 Q86PM1
    Q9VWI6 Q9VWI6

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